UNIGE document Scientific Article
previous document  unige:20573  next document
add to browser collection

Insuline et cancer: mythe ou realité?

Published in Revue médicale suisse. 2010, vol. 6, no. 252, p. 1188-1190, 1192
Abstract Several insulin analogues have been developed in recent years and are increasingly being used in the treatment of diabetes. However, modifying the insulin molecule not only changes its metabolic effects, but can also alter its mitogenic potency. In vitro experiments had previously suggested a potential association between insulin analogues and cancer. In 2009 several articles were published in Diabetologia describing an association between administration of glargine (Lantus) and higher incidence of cancer rates. The present article aims at briefly presenting the state of the art based upon currently available data on insulin and cancer. We will summarize the mechanisms by which insulin can increase cell proliferation, the observations reported in recent publications and finally conclude with some practical recommendations.
Keywords Diabetes Mellitus/drug therapyEvidence-Based MedicineHumansHypoglycemic Agents/administration & dosage/*adverse effectsIncidenceInsulin/administration & dosage/adverse effects/*analogs & derivativesInsulin, Long-ActingNeoplasms/*chemically inducedRisk
PMID: 20614753
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Research group Diabète et régulation des gènes (36)
(ISO format)
TRAN, Christel, GARIANI, Karim, PHILIPPE, Jacques. Insuline et cancer: mythe ou realité?. In: Revue médicale suisse, 2010, vol. 6, n° 252, p. 1188-1190, 1192. https://archive-ouverte.unige.ch/unige:20573

194 hits

0 download


Deposited on : 2012-05-22

Export document
Format :
Citation style :