This manuscript reviews the main vaccine safety concerns that have limited the confidence of the population vis-a-vis influenza A(H1N1) vaccines and disturbed health professionals: A hasty development process? Excessively strong adjuvants? Notoriously toxic substances such as squalene and mercury salts? High risks of Guillain-Barre syndrome or auto-immune diseases? Deaths and other severe problems following immunization? Providing the available information, this manuscript asks whether a high-quality scientific communication would have reassured health professionals, and thus the population. The huge number of questions sent by professionals to InfoVac experts (www.infovac.ch), and the expressed gratitude, allows for some hope.