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Résultats de la transplantation pulmonaire

Quetant, S.
Pison, C.
Published in Revue des maladies respiratoires. 2010, vol. 27, no. 8, p. 921-938
Abstract INTRODUCTION: Lung transplantation has experienced an increasing expansion with a significant improvement in results with the passage of time. Evaluation of these results consists of several domains: survival, function, quality of life and cost-effectiveness. BACKGROUND: The success of lung transplantation is confirmed by a median survival that currently exceeds 5 years. Cystic fibrosis is the disease associated with the best results with, in France, a survival of 76% at 1 year, 56% at 5 years and 47% at 10 years and a median survival of 8 years. According to French data the 5-year survival is 46% for PAHT, 42% for COPD and 36% for pulmonary fibrosis. Studies have shown a survival benefit for cystic fibrosis and interstitial lung disease but definitive conclusions cannot be drawn for patients with COPD. Lung transplantation brings similar benefits in terms of quality of life and cost-effectiveness. VIEWPOINTS: New statistical methods would allow a better estimate in terms of years of survival and quality of life to be made for each candidate on an individual basis. CONCLUSIONS: Lung transplantation improves survival and quality of life compared to medical treatment, at an acceptable cost. These outcomes should be assessed at both an individual and social level to justify the resources involved.
Keywords AdultAge FactorsAgedCost-Benefit AnalysisCystic Fibrosis/mortality/surgeryExercise ToleranceFrance/epidemiologyHumansHypertension, Pulmonary/mortality/surgeryLung Diseases, Interstitial/mortality/surgery*Lung Transplantation/economics/methods/psychology/statistics & numerical dataMiddle AgedPatient SatisfactionPulmonary Disease, Chronic Obstructive/mortality/surgeryPulmonary Emphysema/mortality/surgeryPulmonary Fibrosis/mortality/surgeryQuality of LifeReoperationRespiratory Function TestsRisk FactorsSurvival RateTreatment Outcome
PMID: 20965407
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Research groups L'épithélium respiratoire (852)
Pneumologie Clinique (576)
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QUETANT, S., ROCHAT, Thierry, PISON, C. Résultats de la transplantation pulmonaire. In: Revue des maladies respiratoires, 2010, vol. 27, n° 8, p. 921-938. doi: 10.1016/j.rmr.2010.08.001 https://archive-ouverte.unige.ch/unige:20554

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Deposited on : 2012-05-22

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