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Decreased bone turnover in children and adolescents with well controlled type 1 diabetes

Kraenzlin, M.
Marchand, L. M.
Schwitzgebel, V.
Published in Journal of Pediatric Endocrinology and Metabolism. 2010, vol. 23, no. 7, p. 697-707
Abstract AIM: Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood. PATIENTS AND METHODS: We recruited 27 T1DM children and 32 controls (age 10.5 +/- 2.5 yr.) and measured BMD (dual-energy x-ray absorptiometry); bone biomarkers levels (osteocalcin: OC; procollagen type 1 propeptides amino-terminal: PINP; crosslinking telopeptides of type 1 collagen C-terminal: CTX), glycated hemoglobin (HbA1c), dietary intake and physical activity. RESULTS: Patients with T1DM had lower levels of OC (70.3 +/- 3.3 vs 105.3 +/- 6.8), PINP (556.4 +/- 47.6 vs 716.3 +/- 53.8), CTX(0.97 +/- 0.07 vs 1.20 +/- 0.08), physical activity, and calcium intake. Biomarkers were negatively correlated with HbA1c. Though, BMD was similar among groups and not related to HbA1c, disease duration, physical activity or dietary intakes. CONCLUSIONS: Bone turnover is altered in T1DM children, whereas BMD remains normal during growth. Physical activity and optimal calcium intakes may improve bone metabolism and delay osteoporosis.
Keywords AdolescentBone Density*Bone RemodelingChildCollagen Type I/bloodDiabetes Mellitus, Type 1/complications/*metabolismFemaleHemoglobin A, Glycosylated/analysisHumansMaleOsteocalcin/bloodPeptide Fragments/bloodPeptides/bloodProcollagen/blood
PMID: 20857842
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Research groups Génétique des Ostéoporoses (544)
L'hypertension pulmonaire (pédiatrie) (228)
Nutrition et os (66)
Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
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MAGGIO, Albane Bertha et al. Decreased bone turnover in children and adolescents with well controlled type 1 diabetes. In: Journal of Pediatric Endocrinology and Metabolism, 2010, vol. 23, n° 7, p. 697-707. https://archive-ouverte.unige.ch/unige:20511

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Deposited on : 2012-05-22

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