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Titles listDecreased bone turnover in children and adolescents with well controlled type 1 diabetes
Titles listDecreased bone turnover in children and adolescents with well controlled type 1 diabetes
Scientific Article
unige:20511 
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Decreased bone turnover in children and adolescents with well controlled type 1 diabetes |
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| Authors | ||
| Published in | Journal of Pediatric Endocrinology and Metabolism. 2010, vol. 23, no. 7, p. 697-707 | |
| Abstract | AIM: Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood. PATIENTS AND METHODS: We recruited 27 T1DM children and 32 controls (age 10.5 +/- 2.5 yr.) and measured BMD (dual-energy x-ray absorptiometry); bone biomarkers levels (osteocalcin: OC; procollagen type 1 propeptides amino-terminal: PINP; crosslinking telopeptides of type 1 collagen C-terminal: CTX), glycated hemoglobin (HbA1c), dietary intake and physical activity. RESULTS: Patients with T1DM had lower levels of OC (70.3 +/- 3.3 vs 105.3 +/- 6.8), PINP (556.4 +/- 47.6 vs 716.3 +/- 53.8), CTX(0.97 +/- 0.07 vs 1.20 +/- 0.08), physical activity, and calcium intake. Biomarkers were negatively correlated with HbA1c. Though, BMD was similar among groups and not related to HbA1c, disease duration, physical activity or dietary intakes. CONCLUSIONS: Bone turnover is altered in T1DM children, whereas BMD remains normal during growth. Physical activity and optimal calcium intakes may improve bone metabolism and delay osteoporosis. | |
| Keywords | Adolescent — Bone Density — *Bone Remodeling — Child — Collagen Type I/blood — Diabetes Mellitus, Type 1/complications/*metabolism — Female — Hemoglobin A, Glycosylated/analysis — Humans — Male — Osteocalcin/blood — Peptide Fragments/blood — Peptides/blood — Procollagen/blood | |
| Identifiers | PMID: 20857842 | |
| Full text | ||
| Structures |
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités |
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| Research groups | L'hypertension pulmonaire (pédiatrie) (228) Génétique des Ostéoporoses (544) Nutrition et os (66) Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180) | |
| Citation (ISO format) | MAGGIO, Albane Bertha et al. Decreased bone turnover in children and adolescents with well controlled type 1 diabetes. In: Journal of Pediatric Endocrinology and Metabolism, 2010, vol. 23, n° 7, p. 697-707. https://archive-ouverte.unige.ch/unige:20511 |
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