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Title

Decreased bone turnover in children and adolescents with well controlled type 1 diabetes

Authors
Kraenzlin, M.
Marchand, L. M.
Schwitzgebel, V.
Published in Journal of Pediatric Endocrinology and Metabolism. 2010, vol. 23, no. 7, p. 697-707
Abstract AIM: Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood. PATIENTS AND METHODS: We recruited 27 T1DM children and 32 controls (age 10.5 +/- 2.5 yr.) and measured BMD (dual-energy x-ray absorptiometry); bone biomarkers levels (osteocalcin: OC; procollagen type 1 propeptides amino-terminal: PINP; crosslinking telopeptides of type 1 collagen C-terminal: CTX), glycated hemoglobin (HbA1c), dietary intake and physical activity. RESULTS: Patients with T1DM had lower levels of OC (70.3 +/- 3.3 vs 105.3 +/- 6.8), PINP (556.4 +/- 47.6 vs 716.3 +/- 53.8), CTX(0.97 +/- 0.07 vs 1.20 +/- 0.08), physical activity, and calcium intake. Biomarkers were negatively correlated with HbA1c. Though, BMD was similar among groups and not related to HbA1c, disease duration, physical activity or dietary intakes. CONCLUSIONS: Bone turnover is altered in T1DM children, whereas BMD remains normal during growth. Physical activity and optimal calcium intakes may improve bone metabolism and delay osteoporosis.
Keywords AdolescentBone Density*Bone RemodelingChildCollagen Type I/bloodDiabetes Mellitus, Type 1/complications/*metabolismFemaleHemoglobin A, Glycosylated/analysisHumansMaleOsteocalcin/bloodPeptide Fragments/bloodPeptides/bloodProcollagen/blood
Identifiers
PMID: 20857842
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Structures
Research groups L'hypertension pulmonaire (pédiatrie) (228)
Génétique des Ostéoporoses (544)
Nutrition et os (66)
Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
Citation
(ISO format)
MAGGIO, Albane Bertha et al. Decreased bone turnover in children and adolescents with well controlled type 1 diabetes. In: Journal of Pediatric Endocrinology and Metabolism, 2010, vol. 23, n° 7, p. 697-707. https://archive-ouverte.unige.ch/unige:20511

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Deposited on : 2012-05-22

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