en
Scientific article
English

Decreased bone turnover in children and adolescents with well controlled type 1 diabetes

Published inJournal of pediatric endocrinology & metabolism, vol. 23, no. 7, p. 697-707
Publication date2010
Abstract

AIM: Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood. PATIENTS AND METHODS: We recruited 27 T1DM children and 32 controls (age 10.5 +/- 2.5 yr.) and measured BMD (dual-energy x-ray absorptiometry); bone biomarkers levels (osteocalcin: OC; procollagen type 1 propeptides amino-terminal: PINP; crosslinking telopeptides of type 1 collagen C-terminal: CTX), glycated hemoglobin (HbA1c), dietary intake and physical activity. RESULTS: Patients with T1DM had lower levels of OC (70.3 +/- 3.3 vs 105.3 +/- 6.8), PINP (556.4 +/- 47.6 vs 716.3 +/- 53.8), CTX(0.97 +/- 0.07 vs 1.20 +/- 0.08), physical activity, and calcium intake. Biomarkers were negatively correlated with HbA1c. Though, BMD was similar among groups and not related to HbA1c, disease duration, physical activity or dietary intakes. CONCLUSIONS: Bone turnover is altered in T1DM children, whereas BMD remains normal during growth. Physical activity and optimal calcium intakes may improve bone metabolism and delay osteoporosis.

Keywords
  • Adolescent
  • Bone Density
  • *Bone Remodeling
  • Child
  • Collagen Type I/blood
  • Diabetes Mellitus, Type 1/complications/*metabolism
  • Female
  • Hemoglobin A, Glycosylated/analysis
  • Humans
  • Male
  • Osteocalcin/blood
  • Peptide Fragments/blood
  • Peptides/blood
  • Procollagen/blood
Citation (ISO format)
MAGGIO, Albane Bertha et al. Decreased bone turnover in children and adolescents with well controlled type 1 diabetes. In: Journal of pediatric endocrinology & metabolism, 2010, vol. 23, n° 7, p. 697–707.
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ISSN of the journal0334-018X
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