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Le clopidogrel et ses différents sets: existe-t-il une pertinence clinique?

Kummer, Oliver
Marti, Grischa
Published in Revue médicale suisse. 2010, vol. 6, no. 251, p. 1127-1128, 1130-1122
Abstract Clopidogrel hydrogen sulfate is an antiplatelet agent administered, alone or in combination with acetyl salicylic acid, approved in the prevention of cardiovascular events based on large-scale clinical trials. The new salt formulations clopidogrel where approved based on pharmacokinetic measurements of the inactive prodrug on few healthy volunteers, without any other medication. Clopidogrel hydrogen sulfate has a wide variability in platelet response and the pharmacokinetic of the active metabolite is not dose-linear. Ideally, new clopidogrel salts should be tested for therapeutic equivalence in the target patient population. Should this not be feasible, consistent bioequivalence data should be obtained for the active metabolite, using a properly validated and standardized test method.
Keywords Atracurium/pharmacokinetics/therapeutic useCardiovascular Diseases/blood/*drug therapyChloral Hydrate/pharmacokinetics/therapeutic useClinical Trials as TopicHumansHypnotics and Sedatives/therapeutic useNicotinic Agonists/therapeutic usePlatelet Aggregation/*drug effectsPlatelet Aggregation Inhibitors/pharmacokinetics/*therapeutic useTherapeutic EquivalencyTiclopidine/*analogs & derivatives/pharmacokinetics/therapeutic use
PMID: 20572356
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Research groups Biologie du myocarde (22)
L'athérosclérose et ses complications cliniques (591)
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KUMMER, Oliver et al. Le clopidogrel et ses différents sets: existe-t-il une pertinence clinique?. In: Revue médicale suisse, 2010, vol. 6, n° 251, p. 1127-1128, 1130-1122. https://archive-ouverte.unige.ch/unige:20497

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Deposited on : 2012-05-22

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