Danger sensors are molecular complexes allowing our tissues to be alerted to the presence of cellular damage of various origins. These sensors share a similar structure and activation mechanism relying on the formation of circular platforms, called signalosome. One such molecular complex was called the inflammasome, as it controls the activation of two pro- inflammatory cytokines, Interleukin (IL-)1β and IL-18. Triggers of the inflammasome range from genetic mutations to microbial products, gout crystals, ultraviolet light, nanoparticles and adjuvant chemicals. As a result of this surprising diversity, the inflammasome is the object of much attention in many medical fields, including dermatology. Indeed, the skin is an area of intense exposure to the outside realm of microbes, but also of chemical and physical harm. It not only serves as a barrier protecting inner organs but also plays a key role in recruiting and directing immune responses. This works gives an overview on the molecular and cellular mechanisms regulating danger sensing in the skin, with a focus on the inflammasome, and provides an in-depth look on the research and clinical developments related to this emerging field.