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Galactose recognition by the apicomplexan parasite Toxoplasma gondii

Marchant, Jan
Cowper, Ben
Liu, Yan
Lai, Livia
Pinzan, Camila
Sawmynaden, Kovilen
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Published in Journal of Biological Chemistry. 2012, vol. 287, no. 20, p. 16720-16733
Abstract Toxosplasma gondii is the model parasite of the phylum Apicomplexa, which contains numerous obligate intracellular parasites of medical and veterinary importance, including Eimeria, Sarcocystis, Cryptosporidium, Cyclospora and Plasmodium species. Members of this phylum actively enter host cells by a multi-step process with the help of microneme protein (MIC) complexes that play important roles in motility, host cell attachment, moving junction formation and invasion. Toxoplasma gondii (Tg)MIC1-4-6 complex is the most extensively investigated microneme complex which contributes to host cell recognition and attachment via the action of TgMIC1, a sialic acid-binding adhesin. Here, we report the structure of TgMIC4 and reveal its carbohydrate-binding specificity to a variety of galactose-containing carbohydrate ligands. The lectin is composed of six apple domains in which the fifth domain displays a potent galactose-binding activity, and which is cleaved from the complex during parasite invasion. We propose that galactose recognition by TgMIC4 masks the recognition of the parasite thereby providing protection from galectin-mediated activation of the host immune system.
PMID: 22399295
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Research group Biologie d'un parasite intracellulaire obligatoire (773)
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MARCHANT, Jan et al. Galactose recognition by the apicomplexan parasite Toxoplasma gondii. In: Journal of Biological Chemistry, 2012, vol. 287, n° 20, p. 16720-16733. doi: 10.1074/jbc.M111.325928 https://archive-ouverte.unige.ch/unige:20376

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Deposited on : 2012-05-15

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