Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species

Marro Ramon, Diego; Kalia, Yogeshvar; Delgado Charro, Maria Begona; Guy, Richard H.

doi:10.1023/A:1013370529366

Scientific article

English

Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species

ContributorsMarro Ramon, Diego; Kalia, Yogeshvar

; Delgado Charro, Maria Begona; Guy, Richard H.

Published inPharmaceutical research, vol. 18, no. 12, p. 1709-1713

Publication date2001

Abstract

To identify and quantify, in vitro and in vivo (in humans), the charge-carrying species during transdermal iontophoresis of lidocaine hydrochloride as a function of the concentration of drug relative to that of sodium chloride in the anodal solution.

Keywords

Administration, Cutaneous
Animals
Drug Delivery Systems
Iontophoresis
Lidocaine/administration & dosage/pharmacokinetics
Models, Biological
Skin/metabolism
Swine

Affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

MARRO RAMON, Diego et al. Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species. In: Pharmaceutical research, 2001, vol. 18, n° 12, p. 1709–1713. doi: 10.1023/A:1013370529366

Article (Published version)

Identifiers

PID : unige:20367
DOI : 10.1023/A:1013370529366
PMID : 11785690

Journal ISSN0724-8741

509views

2downloads

Creation08/05/2012 11:31:00

First validation08/05/2012 11:31:00

Update14/03/2023 17:29:20

Status update14/03/2023 17:29:20

Last indexation29/10/2024 19:45:15

Archive ouverte UNIGE

Optimizing iontophoretic drug delivery: identification and distribution of the charge-carrying species

To identify and quantify, in vitro and in vivo (in humans), the charge-carrying species during transdermal iontophoresis of lidocaine hydrochloride as a function of the concentration of drug relative to that of sodium chloride in the anodal solution.

Technical informations