Contributions of electromigration and electroosmosis to iontophoretic drug delivery

Marro Ramon, Diego; Kalia, Yogeshvar; Delgado Charro, Maria Begona; Guy, Richard H.

doi:10.1023/A:1013318412527

Scientific article

English

Contributions of electromigration and electroosmosis to iontophoretic drug delivery

ContributorsMarro Ramon, Diego; Kalia, Yogeshvar

; Delgado Charro, Maria Begona; Guy, Richard H.

Published inPharmaceutical research, vol. 18, no. 12, p. 1701-1708

Publication date2001

Abstract

To determine the electromigration and electroosmotic contributions to the iontophoretic delivery of lidocaine hydrochloride, in addition to the more-lipophilic quinine and propranolol hydrochlorides, in the presence and absence of background electrolyte.

Keywords

Administration, Cutaneous
Animals
Drug Delivery Systems
Electrolytes
Iontophoresis
Lidocaine/administration & dosage/pharmacokinetics
Mannitol/pharmacokinetics
Models, Biological
Osmosis
Propranolol/administration & dosage/pharmacokinetics
Quinine/administration & dosage/pharmacokinetics
Skin/metabolism
Swine

Affiliation

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

MARRO RAMON, Diego et al. Contributions of electromigration and electroosmosis to iontophoretic drug delivery. In: Pharmaceutical research, 2001, vol. 18, n° 12, p. 1701–1708. doi: 10.1023/A:1013318412527

Article (Published version)

Identifiers

PID : unige:20366
DOI : 10.1023/A:1013318412527
PMID : 11785689

ISSN of the journal0724-8741

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Contributions of electromigration and electroosmosis to iontophoretic drug delivery

To determine the electromigration and electroosmotic contributions to the iontophoretic delivery of lidocaine hydrochloride, in addition to the more-lipophilic quinine and propranolol hydrochlorides, in the presence and absence of background electrolyte.

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