en
Scientific article
English

Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis

Published inJournal of Musculoskeletal and Neuronal Interactions, vol. 8, no. 2, p. 94-104
Publication date2008
Abstract

Evidence that leptin regulates bone turnover in part through a central nervous system (CNS)/beta-adrenergic system relay has driven attention towards the potential therapeutic benefits of beta-adrenergic blockade to improve bone mass and strength. beta2- adrenergic receptor-mediated signaling in osteoblasts inhibits bone formation and triggers RANKL-mediated osteoclastogenesis and bone resorption. Mouse models of adrenergic-deficiency, particularly the mouse lacking the beta2-adrenergic receptor, have increased bone mass, more specifically increased trabecular bone volume. In turn, beta-blockers, such as propranolol, were reported to inhibit ovariectomy-induced bone loss. In contrast, a number of experiments in mice and rats suggest that inhibition of beta-adrenergic receptor-mediated signaling does not improve, and could actually be detrimental, for bone mass and microstructure. In humans, epidemiological observations suggested that users of beta-blockers have higher bone mineral density (BMD) and/or a reduced risk of fractures, yet not all studies were concordant. Here we review the evidence for a role of the adrenergic system in the regulation of bone metabolism in vitro and in vivo and provide some new evidence for a dual role of beta-adrenergic receptors 1 and 2 on bone turnover. Furthermore, we will examine the similarities and disparities that may exist in the effects of beta-adrenergic and PTH stimulation on bone metabolism.

Keywords
  • Adrenergic Agents/therapeutic use
  • Adrenergic Agonists/pharmacology
  • Adrenergic Antagonists/pharmacology
  • Animals
  • Bone Remodeling/physiology
  • Bone Resorption/physiopathology
  • Bone and Bones/anatomy & histology/drug effects/metabolism/physiology
  • Humans
  • Osteoclasts/drug effects
  • Osteoporosis/drug therapy
  • Parathyroid Hormone/metabolism
  • Receptors, Adrenergic/metabolism
  • Receptors, Adrenergic, beta-1/metabolism
  • Receptors, Adrenergic, beta-2/metabolism
  • Signal Transduction/physiology
Citation (ISO format)
BONNET, Nicolas, PIERROZ, Dominique, FERRARI, Serge Livio. Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis. In: Journal of Musculoskeletal and Neuronal Interactions, 2008, vol. 8, n° 2, p. 94–104.
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal1108-7161
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