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Title

Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis

Authors
Pierroz, Dominique
Published in Journal of Musculoskeletal and Neuronal Interactions. 2008, vol. 8, no. 2, p. 94-104
Abstract Evidence that leptin regulates bone turnover in part through a central nervous system (CNS)/beta-adrenergic system relay has driven attention towards the potential therapeutic benefits of beta-adrenergic blockade to improve bone mass and strength. beta2- adrenergic receptor-mediated signaling in osteoblasts inhibits bone formation and triggers RANKL-mediated osteoclastogenesis and bone resorption. Mouse models of adrenergic-deficiency, particularly the mouse lacking the beta2-adrenergic receptor, have increased bone mass, more specifically increased trabecular bone volume. In turn, beta-blockers, such as propranolol, were reported to inhibit ovariectomy-induced bone loss. In contrast, a number of experiments in mice and rats suggest that inhibition of beta-adrenergic receptor-mediated signaling does not improve, and could actually be detrimental, for bone mass and microstructure. In humans, epidemiological observations suggested that users of beta-blockers have higher bone mineral density (BMD) and/or a reduced risk of fractures, yet not all studies were concordant. Here we review the evidence for a role of the adrenergic system in the regulation of bone metabolism in vitro and in vivo and provide some new evidence for a dual role of beta-adrenergic receptors 1 and 2 on bone turnover. Furthermore, we will examine the similarities and disparities that may exist in the effects of beta-adrenergic and PTH stimulation on bone metabolism.
Keywords Adrenergic Agents/therapeutic useAdrenergic Agonists/pharmacologyAdrenergic Antagonists/pharmacologyAnimalsBone Remodeling/physiologyBone Resorption/physiopathologyBone and Bones/anatomy & histology/drug effects/metabolism/physiologyHumansOsteoclasts/drug effectsOsteoporosis/drug therapyParathyroid Hormone/metabolismReceptors, Adrenergic/metabolismReceptors, Adrenergic, beta-1/metabolismReceptors, Adrenergic, beta-2/metabolismSignal Transduction/physiology
Identifiers
PMID: 18622078
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Other version: http://www.ismni.org/jmni/pdf/32/02BONNET.pdf
Structures
Research group Génétique des Ostéoporoses (544)
Citation
(ISO format)
BONNET, Nicolas, PIERROZ, Dominique, FERRARI, Serge Livio. Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis. In: Journal of Musculoskeletal and Neuronal Interactions, 2008, vol. 8, n° 2, p. 94-104. https://archive-ouverte.unige.ch/unige:2036

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Deposited on : 2009-06-15

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