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Scientific article
English

Contribution of gender-specific genetic factors to osteoporosis risk

Published inAnnals of human genetics, vol. 72, no. Pt 5, p. 696-714
Publication date2008
Abstract

Common diseases result from the complex relationship between genetic and environmental factors. The aim of this review is to provide perspective for a conceptual framework aimed at studying the interplay of gender-specific genetic and environmental factors in the etiology of complex disease, using osteoporosis as an example. In recent years, gender differences in the heritability of the osteoporosis-related phenotypes have been reported and sex-specific quantitative-trait loci were discovered by linkage studies in humans and mice. Results of numerous allelic association studies also differed by gender. In most cases, it was not clear whether or not this phenomenon should be attributed to the effect of sex-chromosomes, sex hormones, or other intrinsic or extrinsic differences between the genders, such as the level of bioavailable estrogen and of physical activity. We conclude that there is need to consider gender-specific genetic and environmental factors in the planning of future association studies on the etiology of osteoporosis and other complex diseases prevalent in the general population.

Keywords
  • Aged
  • Aged, 80 and over
  • Animals
  • Bone Density/genetics
  • Chromosomes, Human, X/genetics
  • Cohort Studies
  • Disease Models, Animal
  • Environment
  • Female
  • Gonadal Steroid Hormones/physiology
  • Humans
  • Interleukin-6/genetics
  • LDL-Receptor Related Proteins/genetics
  • Linkage (Genetics)
  • Male
  • Middle Aged
  • Osteoporosis/etiology/genetics
  • Quantitative Trait Loci
  • Receptors, Estrogen/genetics
  • Risk Factors
  • Sex Characteristics
Citation (ISO format)
KARASIK, D., FERRARI, Serge Livio. Contribution of gender-specific genetic factors to osteoporosis risk. In: Annals of human genetics, 2008, vol. 72, n° Pt 5, p. 696–714. doi: 10.1111/j.1469-1809.2008.00447.x
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Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal0003-4800
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