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SPAT-1 acts with PLK-1 to regulate PAR polarity and cell cycle progression in the early C. elegans embryo

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Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4384 - 2011/12/07
Abstract During cell division, cell cycle events have to be highly coordinated to happen in a correct order, with the proper timing and only once per division. Asymmetrically dividing cell must also coordinate polarity establishment and maintenance with other events of cell division. The presented work was pursued to study the link between cell cycle progression and cell polarity in asymmetrically dividing cells. An early C. elegans embryo enables simultaneous investigation and identification of proteins that control both these processes. The main players that have emerged from this work are: the mitotic kinase, PLK-1 and its regulator SPAT-1, the homologue of human Bora. As presented in the thesis, SPAT-1 together with PLK-1 controls both PAR polarity and cell cycle timing constituting a link between these events during asymmetric cell division.
Keywords Cell polarityCell cycleAsymmetric cell divisionPolo-like kinase 1Aurora APAR polarityC. elegans
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URN: urn:nbn:ch:unige-202907
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NOATYNSKA, Anna. SPAT-1 acts with PLK-1 to regulate PAR polarity and cell cycle progression in the early C. elegans embryo. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:20290

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Deposited on : 2012-05-09

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