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Title

SPAT-1 acts with PLK-1 to regulate PAR polarity and cell cycle progression in the early C. elegans embryo
Author
Noatynska, Anna
Directors
Gotta, Monica
Karch, François
Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4384 - 2011/12/07
Abstract During cell division, cell cycle events have to be highly coordinated to happen in a correct order, with the proper timing and only once per division. Asymmetrically dividing cell must also coordinate polarity establishment and maintenance with other events of cell division. The presented work was pursued to study the link between cell cycle progression and cell polarity in asymmetrically dividing cells. An early C. elegans embryo enables simultaneous investigation and identification of proteins that control both these processes. The main players that have emerged from this work are: the mitotic kinase, PLK-1 and its regulator SPAT-1, the homologue of human Bora. As presented in the thesis, SPAT-1 together with PLK-1 controls both PAR polarity and cell cycle timing constituting a link between these events during asymmetric cell division.
Keywords Cell polarity — Cell cycle — Asymmetric cell division — Polo-like kinase 1 — Aurora A — PAR polarity — C. elegans
Identifiers
URN: urn:nbn:ch:unige-202907
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Structures
Faculté des sciences / Section de biologie / Département de génétique et évolution
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Citation
(ISO format) 		NOATYNSKA, Anna. SPAT-1 acts with PLK-1 to regulate PAR polarity and cell cycle progression in the early C. elegans embryo. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:20290

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Deposited on : 2012-05-09

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