UNIGE document Scientific Article
previous document  unige:20261  next document
add to browser collection
Title

Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics

Authors
Youle, Richard J
Published in Developmental cell. 2011, vol. 21, no. 1, p. 92-101
Abstract Mitochondria participate in apoptosis through a range of mechanisms that vary between vertebrates and invertebrates. In vertebrates, they release intermembrane space proteins, such as cytochrome c, to promote caspase activation in the cytosol. This process is the result of the loss of integrity of the outer mitochondrial membrane caused by proapoptotic members of the Bcl-2 family. This event is always accompanied by a fissioning of the organelle. Fission of mitochondria has also been reported to participate in apoptosis in Drosophila and Caenorhabditis elegans. However, in these organisms, mitochondrial membrane permeabilization does not occur and the mechanism by which mitochondrial dynamics participates in cell death remains elusive.
Keywords AnimalsApoptosisCell Membrane/chemistry/metabolismHumansMitochondria/metabolismProto-Oncogene Proteins c-bcl-2/metabolism
Identifiers
PMID: 21763611
Full text
Article (Published version) (787 Kb) - public document Free access
Structures
Citation
(ISO format)
MARTINOU, Jean-Claude, YOULE, Richard J. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. In: Developmental cell, 2011, vol. 21, n° 1, p. 92-101. https://archive-ouverte.unige.ch/unige:20261

179 hits

108 downloads

Update

Deposited on : 2012-04-30

Export document
Format :
Citation style :