UNIGE document Scientific Article
previous document  unige:20183  next document
add to browser collection
Title

Persistent correlation of ghrelin plasma levels with body mass index both in stable weight conditions and during gastric-bypass-induced weight loss

Authors
Ybarra, J.
Bobbioni-Harsch, E.
Published in Obesity Surgery. 2009, vol. 19, no. 3, p. 327-331
Collection Open Access - Licence nationale Springer
Abstract BACKGROUND: Studies done on serial changes in plasma ghrelin levels after gastric bypass (GBP) have yielded contrasting results since decreased, unchanged, or increased levels have been reported in the literature. This study investigates whether or not GBP has an inhibitory effect on fasting ghrelin levels independently of weight loss. METHODS: Fasting ghrelin levels were measured in 115 stable body weight females, classified as normal body weight (NW; body mass index (BMI)<25 kg/m2), overweight (OW; BMI 25-30 kg/m2), and obese subjects, divided in three subgroups with increasing BMI (BMI 30-40 kg/m2; BMI 40-50 kg/m2; BMI>50 kg/m2). RESULTS: Each obese subgroup showed significantly lower ghrelin levels as compared to both NW (p<0.0001) and OW subjects (p<0.05 or 0.005); however, no significant differences were observed within the three obese subgroups. Forty-nine obese patients underwent a GBP. Plasma ghrelin, measured at 3, 6, and 12 months after GBP, significantly increased from the sixth month on (p<0.0001). When patients were classified, at each postoperative time point, according to their actual BMI, ghrelin was significantly (p=0.0002) related to postoperative BMI and not significantly different from ghrelin measured in stable body weight conditions. CONCLUSIONS: Fasting ghrelin displays an inversely significant correlation with BMI in both stable body weight conditions and after GBP. No evidence was found that GBP had an effect on fasting ghrelin levels, independent of weight loss.
Keywords AdolescentAdult*Body Mass IndexCase-Control StudiesCohort StudiesFemale*Gastric BypassGhrelin/*bloodHumansMiddle AgedObesity, Morbid/*blood/surgeryTime FactorsWeight Loss/*physiologyYoung Adult
Identifiers
PMID: 18975038
Full text
Structures
Research groups Chirurgie viscérale (104)
Education thérapeutique du patient, diabète et obésité (600)
Citation
(ISO format)
YBARRA, J. et al. Persistent correlation of ghrelin plasma levels with body mass index both in stable weight conditions and during gastric-bypass-induced weight loss. In: Obesity Surgery, 2009, vol. 19, n° 3, p. 327-331. https://archive-ouverte.unige.ch/unige:20183

262 hits

1 download

Update

Deposited on : 2012-04-23

Export document
Format :
Citation style :