en
Scientific article
English

Hippocampal volume and declarative memory function in combat-related PTSD

Published inJournal of the International Neuropsychological Society, vol. 15, no. 6, p. 830-839
Publication date2009
Abstract

The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed.

Keywords
  • Adult
  • Alcoholism/complications/pathology
  • Analysis of Variance
  • Brain Mapping
  • Combat Disorders/*complications
  • Hippocampus/*pathology
  • Humans
  • Learning/physiology
  • Magnetic Resonance Imaging/methods
  • Male
  • Memory Disorders/*etiology
  • Middle Aged
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Psychometrics
  • Statistics as Topic
  • Stress Disorders, Post-Traumatic/*complications
  • Veterans
Citation (ISO format)
WOODWARD, Steven H. et al. Hippocampal volume and declarative memory function in combat-related PTSD. In: Journal of the International Neuropsychological Society, 2009, vol. 15, n° 6, p. 830–839. doi: 10.1017/S1355617709990476
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ISSN of the journal1355-6177
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