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Hippocampal volume and declarative memory function in combat-related PTSD

Woodward, Steven H.
Kaloupek, Danny G.
Grande, Laura J.
Stegman, Wendy K.
Kutter, Catherine J.
Leskin, Loraine
Prestel, Rebecca
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Published in Journal of the International Neuropsychological Society. 2009, vol. 15, no. 6, p. 830-839
Abstract The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed.
Keywords AdultAlcoholism/complications/pathologyAnalysis of VarianceBrain MappingCombat Disorders/*complicationsHippocampus/*pathologyHumansLearning/physiologyMagnetic Resonance Imaging/methodsMaleMemory Disorders/*etiologyMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychometricsStatistics as TopicStress Disorders, Post-Traumatic/*complicationsVeterans
PMID: 19703322
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Research group Laboratoire d'imagerie et de psychopathologie développementale (693)
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WOODWARD, Steven H. et al. Hippocampal volume and declarative memory function in combat-related PTSD. In: Journal of the International Neuropsychological Society, 2009, vol. 15, n° 6, p. 830-839. doi: 10.1017/S1355617709990476 https://archive-ouverte.unige.ch/unige:20179

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Deposited on : 2012-04-23

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