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Recurrence pattern after [(18)F]fluoroethyltyrosine-positron emission tomography-guided radiotherapy for high-grade glioma: a prospective study

Casanova, Nathalie
Rouzaud, Michel
Nouet, Philippe
Vees, Hansjorg
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Published in Radiotherapy and oncology. 2009, vol. 93, no. 3, p. 586-592
Abstract PURPOSE: To assess the failure pattern observed after (18)F fluoroethyltyrosine (FET) planning after chemo- and radiotherapy (RT) for high-grade glioma. METHODS: All patients underwent prospectively RT planning using morphological gross tumour volumes (GTVs) and biological tumour volumes (BTVs). The post-treatment recurrence tumour volumes (RTVs) of 10 patients were transferred on their CT planning. First, failure patterns were defined in terms of percentage of RTV located outside the GTV and BTV. Second, the location of the RTV with respect to the delivered dose distribution was assessed using the RTV's DVHs. Recurrences with >95% of their volume within 95% isodose line were considered as central recurrences. Finally, the relationship between survival and GTV/BTV mismatches was assessed. RESULTS: The median percentages of RTV outside the GTV and BTV were 41.8% (range, 10.5-92.4) and 62.8% (range, 34.2-81.1), respectively. The majority of recurrences (90%) were centrally located. Using a composite target volume planning formalism, the degree of GTV and BTV mismatch did not correlate with survivorship. CONCLUSIONS: The observed failure pattern after FET-PET planning and chemo-RT is primarily central. The target mismatch-survival data suggest that using FET-PET planning may counteract the possibility of BTV-related progression, which may have a detrimental effect on survival.
Keywords AdultAgedAstrocytoma/mortality/pathology/radionuclide imaging/*radiotherapyBrain Neoplasms/mortality/pathology/radionuclide imaging/*radiotherapyFemaleFluorodeoxyglucose F18/*diagnostic useGlioblastoma/mortality/pathology/radionuclide imaging/*radiotherapyHumansMaleMiddle Aged*Neoplasm Recurrence, Local*Positron-Emission TomographyRadiopharmaceuticals/*diagnostic use*Radiotherapy Planning, Computer-AssistedSurvival AnalysisSurvival Rate
PMID: 19782417
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Research groups Ciblage tumoral par anticorps, peptides et nucléotides radiomarqués (221)
Groupe Mirabell Raymond (radio-oncologie) (685)
Groupe Ratib Osman (nouvelles techniques d'imagerie moléculaire) (819)
Groupe Weber Damien (oncologie pédiatrique) (894)
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WEBER, Damien et al. Recurrence pattern after [(18)F]fluoroethyltyrosine-positron emission tomography-guided radiotherapy for high-grade glioma: a prospective study. In: Radiotherapy and oncology, 2009, vol. 93, n° 3, p. 586-592. doi: 10.1016/j.radonc.2009.08.043 https://archive-ouverte.unige.ch/unige:20170

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Deposited on : 2012-04-23

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