Scientific article
Open access

Noninvasive stress testing of myocardial perfusion defects: head-to-head comparison of thallium-201 SPECT to MRI perfusion

Published inJournal of nuclear cardiology, vol. 16, no. 4, p. 549-561
  • Open Access - Licence nationale Springer
Publication date2009

BACKGROUND: To evaluate the diagnostic value of magnetic resonance imaging (MRI) of myocardial perfusion in the assessment of flow-limiting epicardial stenosis in a head-to-head comparison with abnormal thallium-201 ((201)TI) single photon emission tomography (SPECT) studies in patients with predominantly known coronary artery disease (CAD). METHODS AND RESULTS: Twenty-one patients (mean age 65 +/- 10 years) with reversible myocardial perfusion defects on (201)TI-SPECT images during dipyridamole-stimulated hyperemia were recruited for study purpose. Within 5 days of the (201)TI-SPECT study, myocardial perfusion was studied again with MRI during dipyridamole stimulation and at rest. Overall, (201)TI-SPECT identified 30 reversible regional perfusion defects. The sensitivity to detect hypoperfused segments was 70% (21/30) with the GRE-MRI perfusion analysis with (201)TI-SPECT as reference. When patients were subgrouped according to the extent of regional reversible perfusion defects on (201)TI-SPECT, mild- (SDS: 2-4), moderate- (SDS: 5-8), and severe- (SDS > 8) perfusion defects were also identified by GRE-MRI perfusion analysis in 75% (6/8), in 56% (9/16) and 100% (6/6), respectively. CONCLUSIONS: GRE-MRI first-pass stress perfusion imaging may not identify up to 30% of mild-to-moderate perfusion defects in a group of preselected patients with predominantly known CAD and abnormal (201)TI-SPECT studies.

  • Adult
  • Aged
  • Angina Pectoris/diagnosis/radionuclide imaging
  • Coronary Angiography/methods
  • Coronary Artery Disease/diagnosis/radionuclide imaging
  • Female
  • Humans
  • Magnetic Resonance Imaging/*methods
  • Male
  • Middle Aged
  • Myocardial Ischemia/pathology
  • Myocardial Perfusion Imaging/*methods
  • Perfusion
  • Thallium Radioisotopes/*diagnostic use
  • Tomography, Emission-Computed, Single-Photon/*methods
Citation (ISO format)
VINCENTI, Gabriella et al. Noninvasive stress testing of myocardial perfusion defects: head-to-head comparison of thallium-201 SPECT to MRI perfusion. In: Journal of nuclear cardiology, 2009, vol. 16, n° 4, p. 549–561. doi: 10.1007/s12350-009-9097-6
Main files (1)
Article (Published version)
ISSN of the journal1071-3581

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