en
Scientific article
English

Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation

Published inTransplant international, vol. 22, no. 2, p. 182-191
Publication date2009
Abstract

This prospective study assessed lymphocyte subsets in the peripheral blood of 42 islet allograft recipients using flow cytometry from 2 weeks and up to 2 years post-transplantation. Subjects received daclizumab (n = 16), Thymoglobulin (n = 12) or alemtuzumab (n = 14). Alemtuzumab was associated with an early (within 1 month) and transient (up to 6 months) increase in the frequency of CD3(+) CD4(+) Foxp3(+) T cells, while daclizumab induced a near complete loss of these cells (P ≤ 0.001). The frequency of memory CD4(+) T cells was increased following depleting immunosuppression induction with either Thymoglobulin or alemtuzumab (P ≤ 0.05), but remained unchanged while using daclizumab. Alemtuzumab induction resulted in a significant loss of memory B lymphocytes when compared with the other induction groups (P ≤ 0.001). While the clinical significance of these findings remains to be fully determined, the observed altered balance between effector, regulatory and memory cells suggests that the immune status of patients will be affected according to the induction strategy chosen.

Keywords
  • Antibodies, Monoclonal/*pharmacology
  • Antibodies, Monoclonal, Humanized
  • Antibodies, Neoplasm/*pharmacology
  • Antilymphocyte Serum
  • Female
  • Flow Cytometry
  • Humans
  • Immunoglobulin G/*pharmacology
  • Immunosuppressive Agents/*pharmacology
  • Islets of Langerhans Transplantation/*immunology
  • Lymphocyte Subsets/*drug effects/*immunology
  • Male
  • Middle Aged
  • Prospective Studies
Citation (ISO format)
TOSO, Christian et al. Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation. In: Transplant international, 2009, vol. 22, n° 2, p. 182–191. doi: 10.1111/j.1432-2277.2008.00746.x
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ISSN of the journal0934-0874
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