en
Scientific article
Review
English

B-cell responses to vaccination at the extremes of age

Published inNature reviews. Immunology, vol. 9, no. 3, p. 185-194
Publication date2009
Abstract

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.

Keywords
  • Aged
  • Aged, 80 and over
  • Aging/*immunology
  • Animals
  • B-Lymphocytes/*immunology
  • Communicable Diseases/*immunology
  • Humans
  • Immunologic Memory
  • Infant
  • Infant, Newborn
  • Mice
  • *Vaccination
  • Vaccines/*immunology
Citation (ISO format)
SIEGRIST, Claire-Anne, ASPINALL, Richard. B-cell responses to vaccination at the extremes of age. In: Nature reviews. Immunology, 2009, vol. 9, n° 3, p. 185–194. doi: 10.1038/nri2508
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ISSN of the journal1474-1733
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