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B-cell responses to vaccination at the extremes of age

Aspinall, Richard
Published in Nature Reviews Immunology. 2009, vol. 9, no. 3, p. 185-194
Abstract Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.
Keywords AgedAged, 80 and overAging/*immunologyAnimalsB-Lymphocytes/*immunologyCommunicable Diseases/*immunologyHumansImmunologic MemoryInfantInfant, NewbornMice*VaccinationVaccines/*immunology
PMID: 19240757
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Other version: http://www.nature.com/nri/journal/v9/n3/pdf/nri2508.pdf
Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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SIEGRIST, Claire-Anne, ASPINALL, Richard. B-cell responses to vaccination at the extremes of age. In: Nature Reviews Immunology, 2009, vol. 9, n° 3, p. 185-194. https://archive-ouverte.unige.ch/unige:20105

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Deposited on : 2012-04-23

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