Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset

Schorscher-Petcu, Ara; Dupre, Anouk; Tribollet, Eliane

doi:10.1016/j.neulet.2009.06.016

Scientific article

English

Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset

Contributors

Schorscher-Petcu, Ara; Dupre, Anouk; Tribollet, Eliane

Published in

Neuroscience letters, vol. 461, no. 3, p. 217-222

Publication date

2009

Abstract

The aim of this study was to label selectively and to map central vasopressin (AVP) and oxytocin (OT) binding sites in the common marmoset. [(125)I]VPA, a compound selective in rodents and human for the AVP V(1a) receptor, yielded the same labeling pattern as [(3)H]AVP, thus suggesting that most AVP receptors present in the marmoset brain are of the V(1a) subtype. Numerous areas exhibited AVP binding sites, among which the olfactory bulb, the accumbens nucleus, the bed nucleus of the stria terminalis, the hypothalamic suprachiasmatic, arcuate and ventromedial nuclei, the medial amygdaloid nucleus, the nucleus of the solitary tract and the cerebral cortex. Binding sites for [(125)I]OTA, a selective OT receptor antagonist in rat and human, were markedly less abundant than [(125)I]VPA ones, and, to a few exceptions, expressed in different areas. Neither AVP, nor OT binding sites were detected in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei identified by neurophysin immunoreactivity. Marked species-related differences were observed in the distribution of both AVP and OT binding sites. Altogether, our data provide a morphological basis to investigate the function of central AVP and OT in the marmoset.

Keywords

Animals
Arginine Vasopressin/*metabolism
Binding Sites
Brain/anatomy & histology/*metabolism
Callithrix
Female
Iodine Radioisotopes
Male
Oxytocin/*metabolism
Radioligand Assay
Receptors, Oxytocin/antagonists & inhibitors/*metabolism
Receptors, Vasopressin/antagonists & inhibitors/*metabolism
Spinal Cord/anatomy & histology/*metabolism
Tritium

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Citation (ISO format)

SCHORSCHER-PETCU, Ara, DUPRE, Anouk, TRIBOLLET, Eliane. Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset. In: Neuroscience letters, 2009, vol. 461, n° 3, p. 217–222. doi: 10.1016/j.neulet.2009.06.016

Article

Identifiers

PID : unige:20091
DOI : 10.1016/j.neulet.2009.06.016
PMID : 19539696

Additional URL for this publication

http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271072&_user=9565874&_pii=S0304394009008027&_check=y&_origin=article&_zone=toolbar&_coverDate=15-Sep-2009&view=c&originContentFamily=serial&wchp=dGLbVlk-zSkzk&md5=de4a9fef42acde38b1e083b204912944/1-s2.0-S0304394009008027-main.pdf

Journal ISSN

0304-3940

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Creation

23/04/2012 13:32:17

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23/04/2012 13:32:17

Update

14/03/2023 17:27:39

Status update

14/03/2023 17:27:39

Last indexation

29/10/2024 19:38:23

Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation