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Title

Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors

Authors
Campisi, Roxana
Dorsey, Deborah
Prior, John O.
Olschewski, Manfred
Sayre, James
Schelbert, Heinrich R.
Published in European Heart Journal. 2009, vol. 30, no. 8, p. 978-986
Abstract AIMS: The aim of this study was to evaluate the effect of hormone replacement therapy (HRT) on coronary vasomotor function in post-menopausal women (PM) with medically treated cardiovascular risk factors (RFs) in a cross-sectional and a longitudinal follow-up (FU) study. METHODS AND RESULTS: Myocardial blood flow (MBF) response to cold pressor testing (CPT) and during pharmacologically induced hyperaemia was measured with positron emission tomography in pre-menopausal women (CON), in PM with HRT and without HRT, and repeated in PM after a mean FU of 24 +/- 14 months. When compared with CON at baseline, the endothelium-related change in MBF (DeltaMBF) to CPT progressively declined in PM with HRT and without HRT (0.35 +/- 0.23 vs. 0.24 +/- 0.20 and 0.16 +/- 0.12 mL/g/min; P = 0.171 and P = 0.021). In PM without HRT and in those with HRT at baseline but with discontinuation of HRT during FU, the endothelium-related DeltaMBF to CPT was significantly less at FU than at baseline (0.05 +/- 0.19 vs. 0.16 +/- 0.12 and -0.03 +/- 0.14 vs. 0.25 +/- 0.18 mL/g/min; P = 0.023 and P = 0.001), whereas no significant change was observed in PM with HRT (0.19 +/- 0.22 vs. 0.23 +/- 0.22 mL/g/min; P = 0.453). Impaired hyperaemic MBFs when compared with CON were not significantly altered from those at baseline exam. CONCLUSION: Long-term administration of oestrogen may contribute to maintain endothelium-dependent coronary function in PM with medically treated cardiovascular RFs.
Keywords AdultAgedCardiovascular Agents/therapeutic useCardiovascular Diseases/*drug therapy/physiopathologyCold TemperatureCoronary Circulation/*drug effectsCoronary Vessels/drug effectsEndothelium, VascularEpidemiologic Methods*Estrogen Replacement TherapyEstrogens/pharmacologyFemaleHemodynamics/drug effectsHumansMicrocirculation/*drug effectsMiddle AgedPositron-Emission TomographyPostmenopause/*physiologyVasoconstrictor Agents/pharmacologyVasodilator Agents/pharmacologyVasomotor System/*drug effects
Identifiers
PMID: 19251725
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Research group Groupe Schindler Thomas (cardiologie) (890)
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SCHINDLER, Thomas et al. Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors. In: European Heart Journal, 2009, vol. 30, n° 8, p. 978-986. https://archive-ouverte.unige.ch/unige:20082

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Deposited on : 2012-04-23

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