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Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome

Published in Journal of Surgical Oncology. 2009, vol. 99, no. 7, p. 439-446
Abstract BACKGROUND AND OBJECTIVES: Oxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy. METHODS: We then investigated the evolution of hepatic functions and liver regeneration following partial hepatectomy in rats with sinusoidal obstruction syndrome. The sinusoidal obstruction syndrome was induced with a single intragastric administration of monocrotaline (MCT). RESULTS: MCT administration induced obstruction of the hepatic microcirculation and increased portal pressure, hepatic VEGF expression, and Ki67 positive hepatocytes. A mild cholestasis was present without modification of hepatic tests. Following a 70% hepatectomy, liver regeneration was significantly impaired by MCT administration and this impaired regeneration was associated with hepatocellular injury evidenced 1 week after hepatectomy. CONCLUSIONS: The presence of sinusoidal obstruction syndrome impairs hepatic regeneration in this rat model of sinusoidal obstruction syndrome.
Keywords AnimalsAntineoplastic Agents/*adverse effectsColorectal Neoplasms/drug therapyDisease Models, AnimalHepatectomyHepatic Veno-Occlusive Disease/chemically induced/*physiopathology/surgery*Liver RegenerationMonocrotalineOrganoplatinum Compounds/adverse effectsRatsRats, Sprague-Dawley
PMID: 19353590
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Research groups Hépatologie chirurgicale (327)
Physiopathologie de la pancréatite aiguë (601)
Métastases du foie (657)
Pharmacologie et imagerie du foie (664)
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SCHIFFER, Eduardo et al. Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome. In: Journal of Surgical Oncology, 2009, vol. 99, n° 7, p. 439-446. https://archive-ouverte.unige.ch/unige:20079

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Deposited on : 2012-04-23

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