UNIGE document Scientific Article
previous document  unige:20079  next document
add to browser collection
Title

Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome

Authors
Published in Journal of Surgical Oncology. 2009, vol. 99, no. 7, p. 439-446
Abstract BACKGROUND AND OBJECTIVES: Oxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy. METHODS: We then investigated the evolution of hepatic functions and liver regeneration following partial hepatectomy in rats with sinusoidal obstruction syndrome. The sinusoidal obstruction syndrome was induced with a single intragastric administration of monocrotaline (MCT). RESULTS: MCT administration induced obstruction of the hepatic microcirculation and increased portal pressure, hepatic VEGF expression, and Ki67 positive hepatocytes. A mild cholestasis was present without modification of hepatic tests. Following a 70% hepatectomy, liver regeneration was significantly impaired by MCT administration and this impaired regeneration was associated with hepatocellular injury evidenced 1 week after hepatectomy. CONCLUSIONS: The presence of sinusoidal obstruction syndrome impairs hepatic regeneration in this rat model of sinusoidal obstruction syndrome.
Keywords AnimalsAntineoplastic Agents/*adverse effectsColorectal Neoplasms/drug therapyDisease Models, AnimalHepatectomyHepatic Veno-Occlusive Disease/chemically induced/*physiopathology/surgery*Liver RegenerationMonocrotalineOrganoplatinum Compounds/adverse effectsRatsRats, Sprague-Dawley
Identifiers
PMID: 19353590
Full text
Structures
Research groups Hépatologie chirurgicale (327)
Physiopathologie de la pancréatite aiguë (601)
Métastases du foie (657)
Pharmacologie et imagerie du foie (664)
Citation
(ISO format)
SCHIFFER, Eduardo et al. Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome. In: Journal of Surgical Oncology, 2009, vol. 99, n° 7, p. 439-446. https://archive-ouverte.unige.ch/unige:20079

226 hits

0 download

Update

Deposited on : 2012-04-23

Export document
Format :
Citation style :