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Effects of Carnoy's solution on blood vessels of the axillary fossa of rats

Saulacic, N.
Stajcic, Z.
Stojcev Stajcic, Lj
Piattelli, A.
Iizuka, T.
Published in International Journal of Oral and Maxillofacial Surgery. 2009, vol. 38, no. 8, p. 876-879
Abstract Carnoy's solution is applied to reduce the recurrence of odontogenic keratocysts and unicystic ameloblastomas. The deleterious action of this fixative on nerves has been studied but no attention has been paid to its effects on nearby vessels. The aim of this study was to investigate the effects of Carnoy's solution on blood vessels. The rat axillary artery and vein were surgically exposed, soaked with Carnoy's solution and kept in place for 2, 5 or 10 min, depending on the treatment group. The 5-min group was followed for 1, 2 and 3 weeks postoperatively. The vessels in the 2-min and 5-min exposure groups showed histological changes to the vessels, represented by focal loss of the endothelium and hyalinization of the wall. These alterations increased in the 10-min group. The vessels in the 3-week observation period revealed signs of recovery. It is concluded that Carnoy's solution can damage blood vessels but the process is reversible for exposure times less than 5 min.
Keywords Acetic Acid/*pharmacologyAnimalsAxilla/innervationAxillary Artery/*drug effects/pathologyAxillary Vein/*drug effects/pathologyAxons/drug effects/pathologyChloroform/*pharmacologyElastic Tissue/drug effects/pathologyEndothelial Cells/drug effects/pathologyEndothelium, Vascular/drug effects/pathologyEthanol/*pharmacologyFemaleFibrosisFixatives/*pharmacologyHyalin/drug effectsMaleNeurons/drug effects/pathologyRatsRats, WistarSchwann Cells/drug effects/pathologyTime FactorsTunica Intima/drug effects/pathologyWound Healing/physiology
PMID: 19427171
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Research group Groupe Lombardi Tommaso (médecine dentaire) (313)
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SAULACIC, N. et al. Effects of Carnoy's solution on blood vessels of the axillary fossa of rats. In: International Journal of Oral and Maxillofacial Surgery, 2009, vol. 38, n° 8, p. 876-879. https://archive-ouverte.unige.ch/unige:20074

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Deposited on : 2012-04-23

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