Scientific article
English

Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02)

Published inAnnals of oncology, vol. 20, no. 9, p. 1522-1528
Publication date2009
Abstract

BACKGROUND: This multicenter phase II study investigated the efficacy and feasibility of preoperative induction chemotherapy followed by chemoradiation and surgery in patients with esophageal carcinoma. PATIENTS AND METHODS: Patients with locally advanced resectable squamous cell carcinoma or adenocarcinoma of the esophagus received induction chemotherapy with cisplatin 75 mg/m(2) and docetaxel (Taxotere) 75 mg/m(2) on days 1 and 22, followed by radiotherapy of 45 Gy (25 x 1.8 Gy) and concurrent chemotherapy comprising cisplatin 25 mg/m(2) and docetaxel 20 mg/m(2) weekly for 5 weeks, followed by surgery. RESULTS: Sixty-six patients were enrolled at eleven centers and 57 underwent surgery. R0 resection was achieved in 52 patients. Fifteen patients showed complete, 16 patients nearly complete and 26 patients poor pathological remission. Median overall survival was 36.5 months and median event-free survival was 22.8 months. Squamous cell carcinoma and good pathologically documented response were associated with longer survival. Eighty-two percent of all included patients completed neoadjuvant therapy and survived for 30 days after surgery. Dysphagia and mucositis grade 3/4 were infrequent (<9%) during chemoradiation. Five patients (9%) died due to surgical complications. CONCLUSIONS: This neoadjuvant, taxane-containing regimen was efficacious and feasible in patients with locally advanced esophageal cancer in a multicenter, community-based setting and represents a suitable backbone for further investigation.

Keywords
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
  • Carcinoma/mortality/*therapy
  • Cisplatin/administration & dosage/adverse effects
  • Combined Modality Therapy
  • Digestive System Surgical Procedures
  • Esophageal Neoplasms/mortality/*therapy
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • *Neoadjuvant Therapy
  • Neoplasm Staging
  • Radiotherapy
  • Taxoids/administration & dosage/adverse effects
  • Treatment Outcome
Citation (ISO format)
RUHSTALLER, T. et al. Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02). In: Annals of oncology, 2009, vol. 20, n° 9, p. 1522–1528. doi: 10.1093/annonc/mdp045
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ISSN of the journal0923-7534
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