A genome-wide association study of testicular germ cell tumor

Rapley, Elizabeth A.; Turnbull, Clare; Al Olama, Ali Amin; Dermitzakis, Emmanouil; Linger, Rachel; Huddart, Robert A.; Renwick, Anthony; Hughes, Deborah; Hines, Sarah; Seal, Sheila; Morrison, Jonathan; Nsengimana, Jeremie; Deloukas, Panagiotis; Rahman, Nazneen; Bishop, D Timothy; Easton, Douglas F.; Stratton, Michael R.

doi:10.1038/ng.394

Scientific article

English

A genome-wide association study of testicular germ cell tumor

ContributorsRapley, Elizabeth A.; Turnbull, Clare; Al Olama, Ali Amin; Dermitzakis, Emmanouil; Linger, Rachel; Huddart, Robert A.; Renwick, Anthony; Hughes, Deborah; Hines, Sarah; Seal, Sheila; Morrison, Jonathan; Nsengimana, Jeremie; Deloukas, Panagiotis; Rahman, Nazneen; Bishop, D Timothy; Easton, Douglas F.; Stratton, Michael R.

Published inNature genetics, vol. 41, no. 7, p. 807-810

Publication date2009

Abstract

We conducted a genome-wide association study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19-1.58), P = 3 x 10(-13)), chromosome 6 (OR = 1.50 (95% CI = 1.28-1.75), P = 10(-13)) and chromosome 12 (OR = 2.55 (95% CI = 2.05-3.19), P = 10(-31)). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12.

Keywords

Case-Control Studies
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 6
*Genome-Wide Association Study
Great Britain
Humans
Intracellular Signaling Peptides and Proteins/genetics
Male
Neoplasms, Germ Cell and Embryonal/*genetics
Nerve Tissue Proteins/genetics
Polymorphism, Single Nucleotide
Stem Cell Factor/genetics
Testicular Neoplasms/*genetics
Bcl-2 Homologous Antagonist-Killer Protein/genetics

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Research group

Population Genomics and Genetics of Complex Traits (892)

Citation (ISO format)

RAPLEY, Elizabeth A. et al. A genome-wide association study of testicular germ cell tumor. In: Nature genetics, 2009, vol. 41, n° 7, p. 807–810. doi: 10.1038/ng.394

Article

Identifiers

PID : unige:20054
DOI : 10.1038/ng.394
PMID : 19483681

Commercial URLhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871592/pdf/ukmss-5145.pdf

ISSN of the journal1061-4036

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A genome-wide association study of testicular germ cell tumor

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