A genome-wide association study of testicular germ cell tumor

Rapley, Elizabeth A.; Turnbull, Clare; Al Olama, Ali Amin; Dermitzakis, Emmanouil; Linger, Rachel; Huddart, Robert A.; Renwick, Anthony; Hughes, Deborah; Hines, Sarah; Seal, Sheila; Morrison, Jonathan; Nsengimana, Jeremie; Deloukas, Panagiotis; Rahman, Nazneen; Bishop, D Timothy; Easton, Douglas F.; Stratton, Michael R.

doi:10.1038/ng.394

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Title		A genome-wide association study of testicular germ cell tumor
Authors		Rapley, Elizabeth A. Turnbull, Clare Al Olama, Ali Amin Dermitzakis, Emmanouil Linger, Rachel Huddart, Robert A. Renwick, Anthony Hughes, Deborah Hines, Sarah Seal, Sheila Morrison, Jonathan Nsengimana, Jeremie Deloukas, Panagiotis Rahman, Nazneen Bishop, D Timothy Easton, Douglas F. Stratton, Michael R. show all authors [1 - 17]
Published in		Nature genetics. 2009, vol. 41, no. 7, p. 807-810
Abstract		We conducted a genome-wide association study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19-1.58), P = 3 x 10(-13)), chromosome 6 (OR = 1.50 (95% CI = 1.28-1.75), P = 10(-13)) and chromosome 12 (OR = 2.55 (95% CI = 2.05-3.19), P = 10(-31)). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12.
Keywords		Case-Control Studies — Chromosomes, Human, Pair 12 — Chromosomes, Human, Pair 5 — Chromosomes, Human, Pair 6 — Genome-Wide Association Study — Great Britain — Humans — Intracellular Signaling Peptides and Proteins/genetics — Male — Neoplasms, Germ Cell and Embryonal/genetics — Nerve Tissue Proteins/genetics — Polymorphism, Single Nucleotide — Stem Cell Factor/genetics — Testicular Neoplasms/*genetics — Bcl-2 Homologous Antagonist-Killer Protein/genetics
Identifiers		DOI: 10.1038/ng.394 PMID: 19483681
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871592/pdf/ukmss-5145.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research group		Population Genomics and Genetics of Complex Traits (892)
Citation (ISO format)		RAPLEY, Elizabeth A. et al. A genome-wide association study of testicular germ cell tumor. In: Nature Genetics, 2009, vol. 41, n° 7, p. 807-810. doi: 10.1038/ng.394 https://archive-ouverte.unige.ch/unige:20054