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A genome-wide association study of testicular germ cell tumor

Rapley, Elizabeth A.
Turnbull, Clare
Al Olama, Ali Amin
Linger, Rachel
Huddart, Robert A.
Renwick, Anthony
Hughes, Deborah
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Published in Nature genetics. 2009, vol. 41, no. 7, p. 807-810
Abstract We conducted a genome-wide association study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19-1.58), P = 3 x 10(-13)), chromosome 6 (OR = 1.50 (95% CI = 1.28-1.75), P = 10(-13)) and chromosome 12 (OR = 2.55 (95% CI = 2.05-3.19), P = 10(-31)). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12.
Keywords Case-Control StudiesChromosomes, Human, Pair 12Chromosomes, Human, Pair 5Chromosomes, Human, Pair 6*Genome-Wide Association StudyGreat BritainHumansIntracellular Signaling Peptides and Proteins/geneticsMaleNeoplasms, Germ Cell and Embryonal/*geneticsNerve Tissue Proteins/geneticsPolymorphism, Single NucleotideStem Cell Factor/geneticsTesticular Neoplasms/*geneticsBcl-2 Homologous Antagonist-Killer Protein/genetics
PMID: 19483681
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Research group Population Genomics and Genetics of Complex Traits (892)
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RAPLEY, Elizabeth A. et al. A genome-wide association study of testicular germ cell tumor. In: Nature Genetics, 2009, vol. 41, n° 7, p. 807-810. doi: 10.1038/ng.394 https://archive-ouverte.unige.ch/unige:20054

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Deposited on : 2012-04-23

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