UNIGE document Scientific Article
previous document  unige:2005  next document
add to browser collection

Corneal nerves alterations in various types of systemic polyneuropathy, identified by in vivo confocal microscopy

Zhao, C.
Lu, S.
Tajouri, N.
Zhao, K.
Mateo Montoya, A.
show hidden authors show all authors [1 - 9]
Published in Klinische Monatsblätter für Augenheilkunde. 2008, vol. 225, no. 5, p. 413-7
Abstract BACKGROUND: In vivo confocal microscopy (IVCM) is a newly developed application to assess corneal nerve morphology. The purpose of the study is to evaluate the role of IVCM in the assessment of various types of polyneuropathy, and to define alterations of corneal nerves in such conditions. PATIENTS AND METHODS: Eighteen patients with various types of polyneuropathy were characterized by clinical neurological and ophthalmic examinations, as well as by electroneuromyography (ENMG). Full thickness IVCM of corneal nerves was carried out on all patients and 15 age-matched eyes using Heidelberg Retina Tomograph II (HRT II). The subbasal nerve plexus were statistically analysed regarding long nerve fiber density, nerve branch density, nerve thickness, nerve bead number and nerve tortuosity. RESULTS: In subbasal nerve plexus, the following three parameters were significantly reduced in patients with polyneuropathy compared to controls: long nerve fibre density (p < 0.01), nerve branch density (p < 0.001), and nerve bead number (p = 0.001). In addition, the average grade of nerve tortuosity was 2.87 +/- 0.97 in the polyneuropathic group and 1.17 +/- 0.68 in the control group (p < 0.0001). CONCLUSIONS: IVCM allows a non-invasive, in vivo study of corneal nerves with high resolution. It therefore appears invaluable in clinical investigations. IVCM appears to be valuable in a large variety of polyneuropathic conditions.
Keywords AdultAgedAged, 80 and overCornea/innervation/pathologyCranial Nerve Diseases/pathologyFemaleHumansImage Enhancement/methodsMaleMicroscopy, Confocal/methodsMiddle AgedPolyneuropathies/pathologyReproducibility of ResultsSensitivity and Specificity
PMID: 18454383
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Research group Implants rétiniens (143)
(ISO format)
ZHAO, C. et al. Corneal nerves alterations in various types of systemic polyneuropathy, identified by in vivo confocal microscopy. In: Klinische Monatsblätter für Augenheilkunde, 2008, vol. 225, n° 5, p. 413-7. doi: 10.1055/s-2008-1027259 https://archive-ouverte.unige.ch/unige:2005

464 hits

0 download


Deposited on : 2009-06-11

Export document
Format :
Citation style :