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Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons

Piallat, B.
Chabardes, S.
Torres, N.
Fraix, V.
Goetz, L.
Seigneuret, E.
Bardinet, E.
Ferraye, M.
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Published in Neuroscience. 2009, vol. 158, no. 4, p. 1201-1205
Abstract In animals, the pedunculopontine (PPN) and the sub-cuneiform (SCU) nuclei located in the upper brainstem are involved during the processing of gait. Similar functional nuclei are suspected in humans but their role in gait is unclear. Here we show that, using extra-cellular recordings of the PPN/SCU region obtained in two parkinsonian patients, the SCU neurons increased their firing rate without modifying their firing pattern during mimicked steps. We conclude that SCU neurons are activated during gait processes.
Keywords Action Potentials/*physiologyElectrodes, ImplantedGait Disorders, Neurologic/etiology/*pathologyHumansImaging, Three-Dimensional/methodsLocomotion/physiologyNeurons/*physiologyParkinson Disease/complications/surgeryStereotaxic TechniquesTegmentum Mesencephali/*pathologyWakefulness
PMID: 19063948
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Research group Maladie de Parkinson (911)
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PIALLAT, B. et al. Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons. In: Neuroscience, 2009, vol. 158, n° 4, p. 1201-1205. doi: 10.1016/j.neuroscience.2008.10.046 https://archive-ouverte.unige.ch/unige:20033

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Deposited on : 2012-04-23

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