Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons

Piallat, B.; Chabardes, S.; Torres, N.; Fraix, V.; Goetz, L.; Seigneuret, E.; Bardinet, E.; Ferraye, M.; Debu, B.; Krack, Paul; Yelnik, J.; Pollak, Pierre; Benabid, Alim-Louis

doi:10.1016/j.neuroscience.2008.10.046

Scientific article

English

Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons

ContributorsPiallat, B.; Chabardes, S.; Torres, N.; Fraix, V.; Goetz, L.; Seigneuret, E.; Bardinet, E.; Ferraye, M.; Debu, B.; Krack, Paul; Yelnik, J.; Pollak, Pierre; Benabid, Alim-Louis

Published inNeuroscience, vol. 158, no. 4, p. 1201-1205

Publication date2009

Abstract

In animals, the pedunculopontine (PPN) and the sub-cuneiform (SCU) nuclei located in the upper brainstem are involved during the processing of gait. Similar functional nuclei are suspected in humans but their role in gait is unclear. Here we show that, using extra-cellular recordings of the PPN/SCU region obtained in two parkinsonian patients, the SCU neurons increased their firing rate without modifying their firing pattern during mimicked steps. We conclude that SCU neurons are activated during gait processes.

Keywords

Action Potentials/*physiology
Electrodes, Implanted
Gait Disorders, Neurologic/etiology/*pathology
Humans
Imaging, Three-Dimensional/methods
Locomotion/physiology
Neurons/*physiology
Parkinson Disease/complications/surgery
Stereotaxic Techniques
Tegmentum Mesencephali/*pathology
Wakefulness

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research groups

Maladie de Parkinson (911)

Citation (ISO format)

PIALLAT, B. et al. Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons. In: Neuroscience, 2009, vol. 158, n° 4, p. 1201–1205. doi: 10.1016/j.neuroscience.2008.10.046

Article

Identifiers

PID : unige:20033
DOI : 10.1016/j.neuroscience.2008.10.046
PMID : 19063948

Additional URL for this publicationhttp://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271071&_user=9565874&_pii=S030645220801587X&_check=y&_origin=article&_zone=toolbar&_coverDate=18-Feb-2009&view=c&originContentFamily=serial&wchp=dGLbVlV-zSkzV&md5=89d95bf9978db727ef060a4e5440c54e/1-s2.0-S030645220801587X-main.pdf

Journal ISSN0306-4522

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Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons

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