en
Scientific article
Open access
English

The emerging role of the endocannabinoid system in cardiovascular disease

Published inSeminars in immunopathology, vol. 31, no. 1, p. 63-77
Collection
  • Open Access - Licence nationale Springer
Publication date2009
Abstract

Endocannabinoids are endogenous bioactive lipid mediators present both in the brain and various peripheral tissues, which exert their biological effects via interaction with specific G-protein-coupled cannabinoid receptors, the CB(1) and CB(2). Pathological overactivation of the endocannabinoid system (ECS) in various forms of shock and heart failure may contribute to the underlying pathology and cardiodepressive state by the activation of the cardiovascular CB(1) receptors. Furthermore, tonic activation of CB(1) receptors by endocannabinoids has also been implicated in the development of various cardiovascular risk factors in obesity/metabolic syndrome and diabetes, such as plasma lipid alterations, abdominal obesity, hepatic steatosis, inflammation, and insulin and leptin resistance. In contrast, activation of CB(2) receptors in immune cells exerts various immunomodulatory effects, and the CB(2) receptors in endothelial and inflammatory cells appear to limit the endothelial inflammatory response, chemotaxis, and inflammatory cell adhesion and activation in atherosclerosis and reperfusion injury. Here, we will overview the cardiovascular actions of endocannabinoids and the growing body of evidence implicating the dysregulation of the ECS in a variety of cardiovascular diseases. We will also discuss the therapeutic potential of the modulation of the ECS by selective agonists/antagonists in various cardiovascular disorders associated with inflammation and tissue injury, ranging from myocardial infarction and heart failure to atherosclerosis and cardiometabolic disorders.

Keywords
  • Animals
  • Cardiovascular Diseases/*immunology
  • Endocannabinoids/*immunology
  • Fatty Liver/immunology
  • Heart Failure
  • Humans
  • Inflammation/immunology
  • Insulin Resistance/immunology
  • Obesity/immunology
  • Reperfusion Injury/immunology
  • Shock/immunology
Citation (ISO format)
PACHER, Pal, STEFFENS, Sabine. The emerging role of the endocannabinoid system in cardiovascular disease. In: Seminars in immunopathology, 2009, vol. 31, n° 1, p. 63–77. doi: 10.1007/s00281-009-0145-8
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1863-2297
517views
220downloads

Technical informations

Creation04/23/2012 1:24:42 PM
First validation04/23/2012 1:24:42 PM
Update time03/14/2023 5:27:04 PM
Status update03/14/2023 5:27:04 PM
Last indexation01/15/2024 11:28:55 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack