Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
ContributorsNogueiras, Ruben; Perez-Tilve, Diego; Veyrat-Durebex, Christelle; Morgan, Donald A.; Varela, Luis; Haynes, William G.; Patterson, James T.; Disse, Emmanuel; Pfluger, Paul T.; Lopez, Miguel; Woods, Stephen C.; DiMarchi, Richard; Dieguez, Carlos; Rahmouni, Kamal; Rohner-Jeanrenaud, Françoise; Tschop, Matthias H.
Published inThe Journal of neuroscience, vol. 29, no. 18, p. 5916-5925
Publication date2009
Abstract
Keywords
- Adipose Tissue/cytology/metabolism
- Analysis of Variance
- Animals
- Body Composition/drug effects/genetics/physiology
- Central Nervous System/drug effects/*metabolism
- Eating/drug effects
- Energy Metabolism/drug effects/physiology
- Glucagon-Like Peptide 1/pharmacology
- Lipid Metabolism/genetics/*physiology
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Motor Activity/drug effects/physiology
- Obesity/etiology/metabolism/*physiopathology
- Peptide Fragments/pharmacology
- Receptors, Adrenergic, beta/deficiency
- Receptors, Glucagon/antagonists & inhibitors/*physiology
- Signal Transduction/genetics/*physiology
- Sympathetic Nervous System/drug effects/*physiology
- Time Factors
Research group
Citation (ISO format)
NOGUEIRAS, Ruben et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. In: The Journal of neuroscience, 2009, vol. 29, n° 18, p. 5916–5925. doi: 10.1523/JNEUROSCI.5977-08.2009
Main files (1)
Article
Identifiers
- PID : unige:20009
- DOI : 10.1523/JNEUROSCI.5977-08.2009
- PMID : 19420258
Commercial URLhttp://www.jneurosci.org/content/29/18/5916.full.pdf
ISSN of the journal0270-6474