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Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data

Sanyal, Arun J.
Published in Liver International. 2009, vol. 29 Suppl 2, p. 26-37
Abstract Abnormal accumulation of fat in the liver (steatosis) is commonly observed in hepatitis C virus (HCV) infection, and the severity of steatosis has been well correlated with the degree of hepatic fibrosis. In patients with chronic HCV infection, steatosis may occur in conjunction with other metabolic risk factors such as insulin resistance and the metabolic syndrome. This was observed primarily in patients infected with non-genotype 3 virus. Otherwise, in HCV-infected patients, especially those infected with genotype 3a, reductions in total cholesterol as well as high-density lipoprotein and low-density lipoprotein cholesterol are observed compared with matched controls, and the normalization of these parameters appears to be an important correlate of the response to antiviral therapy. In that setting, the pathogenic mechanisms involved in HCV-induced steatosis are mediated in large part by the HCV core protein, whose expression is associated with lipid droplet accumulation, changes in lipogenic gene expression and/or the activity of lipogenic proteins, and effects on mitochondrial oxidative function. The importance of genes such as peroxisome proliferator-activated receptor-alpha and the proteasome activator PA28-gamma in HCV-mediated steatosis has been elucidated from studies in genetically altered mice, and the manipulation of these and other pathways may provide an avenue for therapeutic intervention.
Keywords Fatty Liver/*etiology/*metabolism*Gene Expression RegulationHepacivirus/*geneticsHepatitis C/*complications/geneticsHumansInsulin Resistance/physiology*Lipid MetabolismReactive Oxygen Species/metabolism
PMID: 19187070
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Research group Etudes et traitement de l'hépatite C et B (554)
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NEGRO, Francesco, SANYAL, Arun J. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. In: Liver International, 2009, vol. 29 Suppl 2, p. 26-37. https://archive-ouverte.unige.ch/unige:20003

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Deposited on : 2012-04-23

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