Granzyme A : a stealth killer in the mitochondrion

Lucken-Ardjomande, Safa; Martinou, Jean-Claude

doi:10.1016/j.cell.2008.04.031

Scientific article

English

Granzyme A : a stealth killer in the mitochondrion

Contributors

Lucken-Ardjomande, Safa; Martinou, Jean-Claude

Published in

Cell, vol. 133, p. 568-570

Publication date

2008

Abstract

The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain) leading to production of reactive oxygen species and ultimately to cell death.

Keywords

Animals
Cell Death
Granzymes
Humans
Membrane Potential
Mitochondrial
Mitochondria
NADH Dehydrogenase
Protein Transport
Reactive Oxygen Species
T-Lymphocytes

UNIGE affiliation entities

Faculté des sciences / Section de biologie / Département de biologie cellulaire

Citation (ISO format)

LUCKEN-ARDJOMANDE, Safa, MARTINOU, Jean-Claude. Granzyme A : a stealth killer in the mitochondrion. In: Cell, 2008, vol. 133, p. 568–570. doi: 10.1016/j.cell.2008.04.031

Article (Published version)

Identifiers

PID : unige:20
DOI : 10.1016/j.cell.2008.04.031
PMID : 18485862

Journal ISSN

0092-8674

688views

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Creation

29/10/2008 11:37:32

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29/10/2008 11:37:32

Update

14/03/2023 14:56:29

Status update

14/03/2023 14:56:29

Last indexation

29/10/2024 10:47:12

Granzyme A : a stealth killer in the mitochondrion

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation