Scientific article

Granzyme A : a stealth killer in the mitochondrion

Published inCell, vol. 133, p. 568-570
Publication date2008

The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain) leading to production of reactive oxygen species and ultimately to cell death.

  • Animals
  • Cell Death
  • Granzymes
  • Humans
  • Membrane Potential
  • Mitochondrial
  • Mitochondria
  • NADH Dehydrogenase
  • Protein Transport
  • Reactive Oxygen Species
  • T-Lymphocytes
Citation (ISO format)
LUCKEN-ARDJOMANDE, Safa, MARTINOU, Jean-Claude. Granzyme A : a stealth killer in the mitochondrion. In: Cell, 2008, vol. 133, p. 568–570. doi: 10.1016/j.cell.2008.04.031
Main files (1)
Article (Published version)
ISSN of the journal0092-8674

Technical informations

Creation10/29/2008 11:37:32 AM
First validation10/29/2008 11:37:32 AM
Update time03/14/2023 2:56:29 PM
Status update03/14/2023 2:56:29 PM
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