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Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland

Myers, Catherine
Kind, Christian
Rudin, Christoph
Nadal, David
CollaborationWith : Gervaix, Alain
Published in Pediatric Infectious Disease Journal. 2009, vol. 28, no. 11, p. 996-1001
Abstract BACKGROUND: Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued. METHODS: A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity. RESULTS: Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center. CONCLUSIONS: All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.
Keywords AdolescentAntibodies, Viral/bloodCD4 Lymphocyte CountChildChild, PreschoolCohort StudiesFemaleGuideline Adherence/*statistics & numerical dataHIV Infections/*immunologyHumansMaleProspective StudiesSwitzerlandVaccination/*utilizationVaccines/*immunologyViral LoadYoung Adult
PMID: 19820427
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Research groups Centre de Vaccinologie et d'Immunologie néonatale (177)
Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
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MYERS, Catherine et al. Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland. In: Pediatric Infectious Disease Journal, 2009, vol. 28, n° 11, p. 996-1001. doi: 10.1097/INF.0b013e3181a78348 https://archive-ouverte.unige.ch/unige:19992

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Deposited on : 2012-04-23

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