Scientific article

Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda

Published inTM & IH. Tropical medicine and international health, vol. 14, no. 8, p. 910-917
Publication date2009

OBJECTIVE: To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda. METHODS: Retrospective analysis of VL patients' clinical data collected for project monitoring by Medecins Sans Frontieres in Amudat, eastern Uganda. RESULTS: Between 2000 and 2005, of 3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children <16 years of age with a male/female ratio of 2.2. The overall case-fatality rate during pentavalent antimonial (n = 1641) or conventional amphotericin B treatment (n = 217) was 3.7%. There was no difference in the case-fatality rate between treatment groups (P > 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age <6 years and >15 years, concomitant tuberculosis or hepatopathy, and drug-related adverse events. The case-fatality rate among patients >45 years of age was strikingly high (29.0%). CONCLUSION: Subgroups of VL patients at higher risk of death during treatment with drugs currently available in Uganda were identified. Less toxic drugs should be evaluated and used in these patients.

  • Adolescent
  • Adult
  • Antiprotozoal Agents/administration & dosage/*adverse effects
  • Child
  • Child, Preschool
  • Female
  • *Hospital Mortality
  • Humans
  • Infant
  • Infant, Newborn
  • Leishmaniasis, Visceral/drug therapy/*mortality
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Uganda/epidemiology
  • Young Adult
Citation (ISO format)
MUELLER, Yolanda et al. Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda. In: TM & IH. Tropical medicine and international health, 2009, vol. 14, n° 8, p. 910–917. doi: 10.1111/j.1365-3156.2009.02305.x
Main files (1)
ISSN of the journal1360-2276

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