

Other version: http://www.sciencedirect.com/science/article/pii/S0168827809004589
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Acute hepatitis due to brivudin: a case report |
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Authors | ||
Published in | Journal of hepatology. 2009, vol. 51, no. 5, p. 967-969 | |
Abstract | BACKGROUND/AIMS: Brivudin is licensed in several European countries for the treatment of herpetic infections, and is considered safe (approximately 1% of patients with transient elevation of liver enzymes) in large multicenter trials. METHODS: We report a case of acute brivudin hepatitis documented with a liver biopsy in detail. RESULTS: Liver biopsy demonstrated acute liver injury with a predominant cytolytic pattern and features suggestive of a drug-induced immunoallergic hepatitis. Elevated ALT levels returned to normal within weeks. CONCLUSIONS: This is the first published case of acute immunoallergic hepatitis due to brivudin. | |
Keywords | Adult — Alanine Transaminase/blood — Antiviral Agents/*toxicity — Bilirubin/blood — Bromodeoxyuridine/*analogs & derivatives/toxicity — Drug-Induced Liver Injury/blood/enzymology/*etiology/pathology — Herpes Simplex/drug therapy — Humans — Male | |
Identifiers | PMID: 19692139 | |
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![]() ![]() Other version: http://www.sciencedirect.com/science/article/pii/S0168827809004589 |
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Research group | Métastases du foie (657) | |
Citation (ISO format) | MOTTU, Alexandre et al. Acute hepatitis due to brivudin: a case report. In: Journal of Hepatology, 2009, vol. 51, n° 5, p. 967-969. doi: 10.1016/j.jhep.2009.06.017 https://archive-ouverte.unige.ch/unige:19986 |