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Acute hepatitis due to brivudin: a case report

Mottu, Alexandre
Published in Journal of hepatology. 2009, vol. 51, no. 5, p. 967-969
Abstract BACKGROUND/AIMS: Brivudin is licensed in several European countries for the treatment of herpetic infections, and is considered safe (approximately 1% of patients with transient elevation of liver enzymes) in large multicenter trials. METHODS: We report a case of acute brivudin hepatitis documented with a liver biopsy in detail. RESULTS: Liver biopsy demonstrated acute liver injury with a predominant cytolytic pattern and features suggestive of a drug-induced immunoallergic hepatitis. Elevated ALT levels returned to normal within weeks. CONCLUSIONS: This is the first published case of acute immunoallergic hepatitis due to brivudin.
Keywords AdultAlanine Transaminase/bloodAntiviral Agents/*toxicityBilirubin/bloodBromodeoxyuridine/*analogs & derivatives/toxicityDrug-Induced Liver Injury/blood/enzymology/*etiology/pathologyHerpes Simplex/drug therapyHumansMale
PMID: 19692139
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Research group Métastases du foie (657)
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MOTTU, Alexandre et al. Acute hepatitis due to brivudin: a case report. In: Journal of Hepatology, 2009, vol. 51, n° 5, p. 967-969. doi: 10.1016/j.jhep.2009.06.017 https://archive-ouverte.unige.ch/unige:19986

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Deposited on : 2012-04-23

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