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Title

Acute hepatitis due to brivudin: a case report
Authors
Mottu, Alexandre
Rubbia-Brandt, Laura
Bihl, Florian
Hadengue, Antoine
Spahr, Laurent François Joséph
Published in Journal of Hepatology. 2009, vol. 51, no. 5, p. 967-969
Abstract BACKGROUND/AIMS: Brivudin is licensed in several European countries for the treatment of herpetic infections, and is considered safe (approximately 1% of patients with transient elevation of liver enzymes) in large multicenter trials. METHODS: We report a case of acute brivudin hepatitis documented with a liver biopsy in detail. RESULTS: Liver biopsy demonstrated acute liver injury with a predominant cytolytic pattern and features suggestive of a drug-induced immunoallergic hepatitis. Elevated ALT levels returned to normal within weeks. CONCLUSIONS: This is the first published case of acute immunoallergic hepatitis due to brivudin.
Keywords Adult — Alanine Transaminase/blood — Antiviral Agents/*toxicity — Bilirubin/blood — Bromodeoxyuridine/*analogs & derivatives/toxicity — Drug-Induced Liver Injury/blood/enzymology/*etiology/pathology — Herpes Simplex/drug therapy — Humans — Male
Identifiers
PMID: 19692139
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.sciencedirect.com/science/article/pii/S0168827809004589
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group Métastases du foie (657)
Citation
(ISO format) 		MOTTU, Alexandre et al. Acute hepatitis due to brivudin: a case report. In: Journal of Hepatology, 2009, vol. 51, n° 5, p. 967-969. doi: 10.1016/j.jhep.2009.06.017 https://archive-ouverte.unige.ch/unige:19986

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Deposited on : 2012-04-23

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