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Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib

Montemurro, M.
Schoffski, P.
Reichardt, P.
Gelderblom, H.
Schutte, J.
Hartmann, J. T.
von Moos, R.
Seddon, B.
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Published in European journal of cancer. 2009, vol. 45, no. 13, p. 2293-2297
Abstract Patients diagnosed with advanced gastrointestinal stromal tumours (GISTs) who are resistant or intolerant to both imatinib and second-line sunitinib have a poor prognosis and few therapeutic options. We evaluated the efficacy of nilotinib, a novel tyrosine kinase inhibitor (TKI) in patients pretreated with imatinib and sunitinib. Fifty-two consecutive patients treated with oral nilotinib, 400mg twice daily, within the nilotinib compassionate use programme in 12 European cancer centres, were included in this retrospective analysis. Median age was 59 years (range 24-80), and all patients had WHO performance score better than 3. All patients had failed both imatinib and sunitinib pretreatment, either due to progressing GIST (96%) or intolerance (4%). Five patients (10%; 95% confidence interval (CI) 2-18) responded to nilotinib and 19 patients (37%; 95% CI 24-50) achieved a disease stabilisation. Nilotinib was generally well tolerated, but six patients (12%) discontinued treatment due to intolerance. Median progression-free survival of nilotinib treatment was 12 weeks (95% CI 9-15; range 0-104) and median overall survival was 34 weeks (95% CI 3-65; range 2-135). Nilotinib is active in GIST resistant to both imatinib and sunitinib. These results warrant further investigation of nilotinib in GIST.
Keywords AdultAgedAged, 80 and overAntineoplastic Agents/*administration & dosage/adverse effectsDisease-Free Survival*Drug Resistance, NeoplasmFemaleGastrointestinal Stromal Tumors/*drug therapy/mortalityHumansIndoles/adverse effectsMaleMiddle AgedPatient SelectionPiperazines/adverse effectsPyrimidines/*administration & dosage/adverse effectsPyrroles/adverse effectsRetrospective StudiesTreatment OutcomeYoung Adult
PMID: 19467857
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Research group Groupe Roth Arnaud (oncologie) (285)
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MONTEMURRO, M. et al. Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib. In: European Journal of Cancer, 2009, vol. 45, n° 13, p. 2293-2297. doi: 10.1016/j.ejca.2009.04.030 https://archive-ouverte.unige.ch/unige:19984

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Deposited on : 2012-04-23

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