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Statins, ACE inhibitors and ARBs in cardiovascular disease

Published in Best Practice & Research: Clinical Endocrinology & Metabolism. 2009, vol. 23, no. 3, p. 389-400
Abstract Atherosclerotic cardiovascular disease (CVD) is the main cause of death in developed and developing countries. It is well accepted that several diseases - including hypertension, dyslipidemia and diabetes mellitus - increase CVD. More recently also chronic inflammatory diseases, such as rheumatoid arthritis, have been shown to accelerate CVD. This association further supports a responsible role for inflammatory processes in all stages of CVD pathophysiology. Clinically, CVD ranges through different acute and chronic syndromes with ischemic symptoms in distal tissues, including heart, cerebral region or peripheral arteries. Several treatments for reducing CVD are under investigation. In this review we focus on statins, angiotensin-converting-enzyme (ACE) inhibitors, and angiotensin-II receptor blockers (ARBs), updating therapeutic evidence from the last clinical trials with particular relevance to diabetic patients.
Keywords Acute Coronary Syndrome/drug therapyAngiotensin II Type 1 Receptor Blockers/*therapeutic useAngiotensin-Converting Enzyme Inhibitors/*therapeutic useCardiovascular Diseases/*drug therapyClinical Trials as TopicCoronary Artery Disease/drug therapyHumansHydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
PMID: 19520311
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Research groups Biologie du myocarde (22)
L'athérosclérose et ses complications cliniques (591)
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MONTECUCCO, Fabrizio, MACH, François. Statins, ACE inhibitors and ARBs in cardiovascular disease. In: Best Practice & Research: Clinical Endocrinology & Metabolism, 2009, vol. 23, n° 3, p. 389-400. doi: 10.1016/j.beem.2008.12.003 https://archive-ouverte.unige.ch/unige:19980

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Deposited on : 2012-04-23

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