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Update on statin-mediated anti-inflammatory activities in atherosclerosis

Published in Seminars in Immunopathology. 2009, vol. 31, no. 1, p. 127-142
Collection Open Access - Licence nationale Springer
Abstract Anti-inflammatory activities of statins in atherosclerosis have been well documented by both basic research and clinical studies. Statins have been introduced in the 1980s as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to block cholesterol synthesis and lower cholesterol serum levels. In the last three decades, statins have been shown to possess several anti-inflammatory and antioxidant activities resulting in the beneficial reduction of atherosclerotic processes and cardiovascular risk in both humans and animal models. Inflammatory intracellular pathways involving kinase phosphorylation and protein prenylation are modulated by statins. The same intracellular mechanisms might also cause statin-induced myotoxicity. In the present review, we will update evidence on statin-mediated regulation of inflammatory pathways in atherogenesis.
Keywords AnimalsAnti-Inflammatory Agents/*immunology/therapeutic useAntioxidantsAtherosclerosis/drug therapy/*immunologyCholesterol/immunologyDisease Models, AnimalHumansHydroxymethylglutaryl-CoA Reductase Inhibitors/*immunology/therapeutic useInflammation/drug therapy/immunologySignal Transduction/drug effects/immunology
PMID: 19415282
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Research groups Biologie du myocarde (22)
L'athérosclérose et ses complications cliniques (591)
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MONTECUCCO, Fabrizio, MACH, François. Update on statin-mediated anti-inflammatory activities in atherosclerosis. In: Seminars in Immunopathology, 2009, vol. 31, n° 1, p. 127-142. doi: 10.1007/s00281-009-0150-y https://archive-ouverte.unige.ch/unige:19979

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Deposited on : 2012-04-23

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