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Scientific article
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Update on statin-mediated anti-inflammatory activities in atherosclerosis

Contributors

Montecucco, Fabrizio; Mach, François

Published in

Seminars in immunopathology, vol. 31, no. 1, p. 127-142

Collection

  • Open Access - Licence nationale Springer

Publication date

2009

Abstract

Anti-inflammatory activities of statins in atherosclerosis have been well documented by both basic research and clinical studies. Statins have been introduced in the 1980s as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to block cholesterol synthesis and lower cholesterol serum levels. In the last three decades, statins have been shown to possess several anti-inflammatory and antioxidant activities resulting in the beneficial reduction of atherosclerotic processes and cardiovascular risk in both humans and animal models. Inflammatory intracellular pathways involving kinase phosphorylation and protein prenylation are modulated by statins. The same intracellular mechanisms might also cause statin-induced myotoxicity. In the present review, we will update evidence on statin-mediated regulation of inflammatory pathways in atherogenesis.

Keywords

  • Animals
  • Anti-Inflammatory Agents/immunology/therapeutic use
  • Antioxidants
  • Atherosclerosis/drug therapy/immunology
  • Cholesterol/immunology
  • Disease Models, Animal
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/immunology/therapeutic use
  • Inflammation/drug therapy/immunology
  • Signal Transduction/drug effects/immunology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MONTECUCCO, Fabrizio, MACH, François. Update on statin-mediated anti-inflammatory activities in atherosclerosis. In: Seminars in immunopathology, 2009, vol. 31, n° 1, p. 127–142. doi: 10.1007/s00281-009-0150-y

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://www.springerlink.com/content/xh2388383kp88707/fulltext.pdf

Journal ISSN

1863-2297
529views
683downloads

Technical informations

Creation

23/04/2012 13:24:28

First validation

23/04/2012 13:24:28

Update

21/01/2025 16:16:02

Status update

21/01/2025 16:16:02

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