Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome

Montecucco, Fabrizio; Mach, François

doi:10.1111/j.1463-1326.2008.00986.x

Scientific article

English

Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome

Contributors

Montecucco, Fabrizio; Mach, François

Published in

Diabetes, obesity & metabolism, vol. 11, no. 5, p. 445-454

Publication date

2009

Abstract

Changes in diagnostic criteria have impacted on the definition of the metabolic syndrome. The central aetiological importance of insulin resistance has lessened, while the role of other cardiovascular risk factors has progressively increased. Inflammatory mediators have also been identified as crucial targets for more selective therapies in metabolic syndrome. Among several pro-inflammatory factors, adiponectin has been shown to be associated with reduced cardiovascular risk in metabolic syndrome patients. Here, we review new therapeutic approaches, which could potentially increase adiponectin levels in metabolic syndrome.

Keywords

Adiponectin/metabolism
Angiotensin II Type 1 Receptor Blockers/pharmacology
Angiotensin-Converting Enzyme Inhibitors/pharmacology
Animals
Cardiovascular Diseases/complications/prevention & control
Clofibric Acid/pharmacology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology
Insulin Resistance
Metabolic Syndrome X/complications/drug therapy
Mice
Peroxisome Proliferator-Activated Receptors/agonists
Receptors, Cannabinoid/antagonists & inhibitors
Risk Factors

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

UNIGE research groups

Citation (ISO format)

MONTECUCCO, Fabrizio, MACH, François. Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome. In: Diabetes, obesity & metabolism, 2009, vol. 11, n° 5, p. 445–454. doi: 10.1111/j.1463-1326.2008.00986.x

Article (Published version)

Identifiers

PID : unige:19977
DOI : 10.1111/j.1463-1326.2008.00986.x
PMID : 19220391

Journal ISSN

1462-8902

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Creation

23/04/2012 13:24:28

First validation

23/04/2012 13:24:28

Update

13/02/2026 15:19:28

Status update

13/02/2026 15:19:28

Last indexation

13/02/2026 15:19:29

Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation