en
Scientific article
English

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Published inEye, vol. 23, no. 9, p. 1836-1844
Publication date2009
Abstract

AIMS: To report corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant in eyes with refractory glaucoma. METHODS: Ten eyes underwent Ahmed valve implant surgery and were followed-up for 12 months. Data collected included intraocular pressure (IOP), number of antiglaucoma medications and surgery-related complications. At 6 and 12 months postoperatively, the intracameral length of the drainage tube (ICL) and the distance between the tube and the cornea (T-C distance), and the iris (T-I distance) were assessed using anterior segment optical coherence tomography (AS-OCT). Heidelberg cornea tomograph II (HRT II) was used to measure the corneal endothelial cell density. RESULTS: Mean (+/-SEM) preoperative IOP was 29.5+/-4 mmHg. Mean postoperative IOP was 11.6+/-2 at 12 months (P<0.01). Over a 6-month period, mean corneal endothelial loss was 7.9%+/-2.5 in the central and 7.5%+/-2.4 in the peripheral cornea (P<0.01). There was no correlation between central or peripheral corneal endothelial cell loss and the T-C, T-I distance or the ICL of the tube. CONCLUSIONS: Corneal endothelial cell loss occurs following Ahmed valve implant surgery, this appears to be multifactorial. AS-OCT and HRT II are promising methods for the follow-up of patients with a glaucoma drainage device.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents/therapeutic use
  • Corneal Endothelial Cell Loss/*pathology
  • Female
  • Follow-Up Studies
  • Glaucoma/*pathology/physiopathology/*surgery
  • *Glaucoma Drainage Implants
  • Humans
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Tomography, Optical Coherence/*methods
  • Young Adult
Citation (ISO format)
MENDRINOS, Efstratios et al. Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant. In: Eye, 2009, vol. 23, n° 9, p. 1836–1844. doi: 10.1038/eye.2008.321
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ISSN of the journal0950-222X
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