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Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

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Published in Eye (London). 2009, vol. 23, no. 9, p. 1836-1844
Abstract AIMS: To report corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant in eyes with refractory glaucoma. METHODS: Ten eyes underwent Ahmed valve implant surgery and were followed-up for 12 months. Data collected included intraocular pressure (IOP), number of antiglaucoma medications and surgery-related complications. At 6 and 12 months postoperatively, the intracameral length of the drainage tube (ICL) and the distance between the tube and the cornea (T-C distance), and the iris (T-I distance) were assessed using anterior segment optical coherence tomography (AS-OCT). Heidelberg cornea tomograph II (HRT II) was used to measure the corneal endothelial cell density. RESULTS: Mean (+/-SEM) preoperative IOP was 29.5+/-4 mmHg. Mean postoperative IOP was 11.6+/-2 at 12 months (P<0.01). Over a 6-month period, mean corneal endothelial loss was 7.9%+/-2.5 in the central and 7.5%+/-2.4 in the peripheral cornea (P<0.01). There was no correlation between central or peripheral corneal endothelial cell loss and the T-C, T-I distance or the ICL of the tube. CONCLUSIONS: Corneal endothelial cell loss occurs following Ahmed valve implant surgery, this appears to be multifactorial. AS-OCT and HRT II are promising methods for the follow-up of patients with a glaucoma drainage device.
Keywords AdolescentAdultAgedAged, 80 and overAntihypertensive Agents/therapeutic useCorneal Endothelial Cell Loss/*pathologyFemaleFollow-Up StudiesGlaucoma/*pathology/physiopathology/*surgery*Glaucoma Drainage ImplantsHumansIntraocular PressureMaleMiddle AgedTomography, Optical Coherence/*methodsYoung Adult
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PMID: 18949003
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MENDRINOS, Efstratios et al. Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant. In: Eye (London), 2009, vol. 23, n° 9, p. 1836-1844. https://archive-ouverte.unige.ch/unige:19954

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Deposited on : 2012-04-23

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