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Proteomics in human Parkinson's disease research

Published in Journal of Proteomics. 2009, vol. 73, no. 1, p. 10-29
Abstract During the last decades, considerable advances in the understanding of specific mechanisms underlying neurodegeneration in Parkinson's disease have been achieved, yet neither definite etiology nor unifying sequence of molecular events has been formally established. Current unmet needs in Parkinson's disease research include exploring new hypotheses regarding disease susceptibility, occurrence and progression, identifying reliable diagnostic, prognostic and therapeutic biomarkers, and translating basic research into appropriate disease-modifying strategies. The most popular view proposes that Parkinson's disease results from the complex interplay between genetic and environmental factors and mechanisms believed to be at work include oxidative stress, mitochondrial dysfunction, excitotoxicity, iron deposition and inflammation. More recently, a plethora of data has accumulated pinpointing an abnormal processing of the neuronal protein alpha-synuclein as a pivotal mechanism leading to aggregation, inclusions formation and degeneration. This protein-oriented scenario logically opens the door to the application of proteomic strategies to this field of research. We here review the current literature on proteomics applied to Parkinson's disease research, with particular emphasis on pathogenesis of sporadic Parkinson's disease in humans. We propose the view that Parkinson's disease may be an acquired or genetically-determined brain proteinopathy involving an abnormal processing of several, rather than individual neuronal proteins, and discuss some pre-analytical and analytical developments in proteomics that may help in verifying this concept.
Keywords Biomedical Research/trendsBrain/metabolism/pathologyDisease ProgressionHumansLewy Bodies/metabolism/pathologyNerve Degeneration/etiology/metabolismParkinson Disease/cerebrospinal fluid/etiology/*metabolism/pathologyProtein Processing, Post-Translational/physiologyProteome/analysis*Proteomics/methods
PMID: 19632367
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Research groups Groupe Pierre Burkhard (neurologie) (154)
La protéomique au service de la clinique (270)
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LICKER, Virginie et al. Proteomics in human Parkinson's disease research. In: Journal of Proteomics, 2009, vol. 73, n° 1, p. 10-29. doi: 10.1016/j.jprot.2009.07.007 https://archive-ouverte.unige.ch/unige:19924

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Deposited on : 2012-04-23

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