Scientific article

Genome-wide association study of blood pressure and hypertension

Published inNature genetics, vol. 41, no. 6, p. 677-687
Publication date2009

Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 x 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 x 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.

  • Blood Pressure/*genetics
  • Cell Line
  • Chromosome Mapping
  • Chromosomes, Human/genetics
  • Diastole/genetics
  • Gene Expression Regulation
  • *Genetic Association Studies
  • *Genome-Wide Association Study
  • Humans
  • Hypertension/epidemiology/*genetics
  • Liver/physiology/physiopathology
  • Lymphocytes/physiology
  • Meta-Analysis as Topic
  • Odds Ratio
  • Phenotype
  • Prevalence
  • Risk Assessment
  • Systole/genetics
Citation (ISO format)
EHRET, Georg Benedikt. Genome-wide association study of blood pressure and hypertension. In: Nature genetics, 2009, vol. 41, n° 6, p. 677–687. doi: 10.1038/ng.384
Main files (1)
ISSN of the journal1061-4036

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