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Reversible acquired epileptic frontal syndrome and CSWS suppression in a child with congenital hemiparesis treated by hemispherotomy

Kallay, Christine
Mayor-Dubois, Claire
Maeder-Ingvar, Malin
Debatisse, Damien
Deonna, Thierry
Roulet-Perez, Eliane
Published in European Journal of Paediatric Neurology. 2009, vol. 13, no. 5, p. 430-438
Abstract A boy with a right congenital hemiparesis due to a left pre-natal middle cerebral artery infarct developed focal epilepsy at 33 months and then an insidious and subsequently more rapid, massive cognitive and behavioural regression with a frontal syndrome between the ages of 4 and 5 years with continuous spike-waves during sleep (CSWS) on the EEG. Both the epilepsy and the CSWS were immediately suppressed by hemispherotomy at the age of 5 years and 4 months. A behavioural-cognitive follow-up prior to hemispherotomy, an per-operative EEG and corticography and serial post-operative neuropsychological assessments were performed until the age of 11 years. The spread of the epileptic activity to the "healthy" frontal region was the cause of the reversible frontal syndrome. A later gradual long-term but incomplete cognitive recovery, with moderate mental disability was documented. This outcome is probably explained by another facet of the epilepsy, namely the structural effects of prolonged epileptic discharges in rapidly developing cerebral networks which are, at the same time undergoing the reorganization imposed by a unilateral early hemispheric lesion. Group studies on the outcome of children before and after hemispherectomy using only single IQ measures, pre- and post-operatively, may miss particular epileptic cognitive dysfunctions as they are likely to be different from case to case. Such detailed and rarely available complementary clinical and EEG data obtained in a single case at different time periods in relation to the epilepsy, including per-operative electrophysiological findings, may help to understand the different cognitive deficits and recovery profiles and the limits of full cognitive recovery.
Keywords Attention/physiologyChildChild DevelopmentChild, Preschool*ElectroencephalographyElectrophysiologyEmotions/physiologyEpilepsy, Frontal Lobe/etiology/surgery/*therapyHumansInfarction, Middle Cerebral Artery/complications/congenitalMagnetic Resonance ImagingMaleNeurologic ExaminationNeuropsychological Tests*Neurosurgical ProceduresParesis/complications/*congenital/*surgerySeizures/physiopathologySleep Disorders/etiology/pathology/*therapySocial BehaviorTime PerceptionTreatment Outcome
PMID: 18945626
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Research group Epilepsie et Chirurgie (149)
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KALLAY, Christine et al. Reversible acquired epileptic frontal syndrome and CSWS suppression in a child with congenital hemiparesis treated by hemispherotomy. In: European Journal of Paediatric Neurology, 2009, vol. 13, n° 5, p. 430-438. https://archive-ouverte.unige.ch/unige:19883

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Deposited on : 2012-04-23

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