Scientific article
Open access

When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship

Published inCritical care, vol. 13, no. 4, 165
Publication date2009

Every day, critical care physicians around the world face the same challenge of the optimal timing of antimicrobial administration: when to start and when to stop antibiotics. Duration of antibiotic therapy for sepsis is mostly based on expert opinion, but its reduction is arguably the most promising approach to decrease emergence and selection of antibiotic resistance. The study by Hochreiter and colleagues presents another piece of evidence suggesting that procalcitonin may indeed be a valuable diagnostic parameter to guide antibiotic treatment duration, despite the ongoing controversy about the diagnostic accuracy of pro-calcitonin.

  • Anti-Bacterial Agents/administration & dosage/*therapeutic use
  • Calcitonin/*blood
  • Critical Illness
  • Decision Making
  • *Drug Administration Schedule
  • *Evidence-Based Medicine
  • Humans
  • Protein Precursors/*blood
  • Sepsis/drug therapy
  • Time Factors
Citation (ISO format)
HARBARTH, Stéphan Juergen, ALBRICH, Werner C., MULLER, Beat. When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship. In: Critical care, 2009, vol. 13, n° 4, p. 165. doi: 10.1186/cc7935
Main files (1)
ISSN of the journal1364-8535

Technical informations

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