en
Scientific article
English

Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis

Published inCancer, vol. 115, no. 20, p. 4715-4726
Publication date2009
Abstract

BACKGROUND: It was investigated whether the European Group for Blood and Marrow Transplantation risk score, previously established for chronic myeloid leukemia, could be used to predict outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological disease in general. METHODS: Age of patient, disease stage, time interval from diagnosis to transplant, donor type, and donor-recipient sex combination were used to establish a score from 0 to 7 points. Its validity was tested in 56,505 patients, 33,113 (58%) male, 23,392 female, median age 33 years (range, 0.5-77 years), with an allogeneic HSCT for a hematological disorder between 1980 and 2005. RESULTS: Survival probability at 5 years decreased from 71% (95% confidence interval [CI], 69%-73%) for risk score 0 for the whole cohort (75%, 95% CI, 72%-78% for the most recent time cohort) to 24% (95% CI, 21%-27% for risk score 6 and 7; 25%, 95% CI, 22%-29% most recent cohort). Transplant-related mortality increased from 15% (95% CI, 14%-17%) for risk score 0 (11%, 95% CI, 9%-13%, most recent cohort) to 47% with risk score 6 and 7 (95% CI, 44%-50%) for the whole cohort (45%, 95% CI, 42%-48%, most recent cohort). The risk score was predictive in all disease categories, over all time periods, and was not altered by transplant techniques. CONCLUSIONS: Five well-defined pretransplant patient and donor characteristics give a reasonable risk estimate of allogeneic HSCT. This risk score can provide a basis for the decision between transplant and nontransplant strategies.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Female
  • Hematologic Diseases/*surgery
  • *Hematopoietic Stem Cell Transplantation/mortality
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk
  • Transplantation, Homologous
Citation (ISO format)
GRATWOHL, Alois et al. Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. In: Cancer, 2009, vol. 115, n° 20, p. 4715–4726. doi: 10.1002/cncr.24531
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0008-543X
464views
0downloads

Technical informations

Creation04/23/2012 1:23:43 PM
First validation04/23/2012 1:23:43 PM
Update time03/14/2023 5:25:15 PM
Status update03/14/2023 5:25:15 PM
Last indexation02/12/2024 7:59:09 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack