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Gene therapy and protein therapy of ectodermal dysplasias: a perspective

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Published in American Journal of Medical Genetics. A. 2009, vol. 149A, no. 9, p. 2042-2044
Abstract Ectodermal dysplasias (EDs) form a complex and heterogeneous group of diseases currently defined and classified according to their clinical symptoms. The characterization, for several EDs, of the molecular events underlying their development, not only challenges this classification but also opens the door to new therapeutic options such as gene or protein therapy. This article provides a concise overview of the most recent successes and failures of this new type of treatment and sets in perspective how the specificities of given EDs will influence their feasibility in the near future. It makes the case for the need of new classification of EDs that is based on our most recent knowledge of the molecular basis of these diseases.
Keywords Ectodermal Dysplasia/diagnosis/genetics/*therapyEctodysplasins/genetics/*therapeutic use*Gene TherapyHumansProteins/genetics/*therapeutic use
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PMID: 19681129
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Research group Voies d'activation de l'immunité innée au niveau de la peau (156)
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GAIDE, Olivier. Gene therapy and protein therapy of ectodermal dysplasias: a perspective. In: American Journal of Medical Genetics. A, 2009, vol. 149A, n° 9, p. 2042-2044. https://archive-ouverte.unige.ch/unige:19820

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Deposited on : 2012-04-23

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