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Pedunculopontine nucleus stimulation induces monocular oscillopsia

Ferraye, M. U.
Gerardin, P.
Debu, B.
Chabardes, S.
Fraix, V.
Seigneuret, E.
LeBas, J-F
Benabid, Alim-Louis
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Published in Journal of Neurology, Neurosurgery, and Psychiatry. 2009, vol. 80, no. 2, p. 228-231
Abstract Two patients with Parkinson's disease with pedunculopontine nucleus (PPN) stimulation for gait impairments reported "trembling vision" during the setting of the electrical parameters, although there was no clinically observable abnormal eye movement. Oculomotor recordings revealed frequency locked voltage dependent vertical or oblique movements of the eye ipsilateral to the active contact, suggesting current spreading to the mesencephalic oculomotor fibres. These results emphasise the difficulty of stimulating this mesencephalic region.
Keywords AgedAntiparkinson Agents/*therapeutic useElectric Stimulation/adverse effectsElectrodes, ImplantedEye Movements/*physiologyGait Disorders, Neurologic/*drug therapy/*etiologyHumansLevodopa/*therapeutic useMesencephalon/*physiologyOculomotor Nerve Diseases/*etiology/*physiopathologyParkinson Disease/*complications/*drug therapyPedunculopontine Tegmental Nucleus/*physiologyVision, Monocular/*physiology
PMID: 19151020
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Other version: http://jnnp.bmj.com/content/80/2/228.full.pdf
Research group Maladie de Parkinson (911)
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FERRAYE, M. U. et al. Pedunculopontine nucleus stimulation induces monocular oscillopsia. In: Journal of Neurology, Neurosurgery, and Psychiatry, 2009, vol. 80, n° 2, p. 228-231. https://archive-ouverte.unige.ch/unige:19809

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Deposited on : 2012-04-23

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