UNIGE document Scientific Article
previous document  unige:19800  next document
add to browser collection

Multiscale modeling of form and function

Engler, Adam J.
Humbert, Patrick O.
Weaver, Valérie M.
Published in Science. 2009, vol. 324, no. 5924, p. 208-212
Abstract Topobiology posits that morphogenesis is driven by differential adhesive interactions among heterogeneous cell populations. This paradigm has been revised to include force-dependent molecular switches, cell and tissue tension, and reciprocal interactions with the microenvironment. It is now appreciated that tissue development is executed through conserved decision-making modules that operate on multiple length scales from the molecular and subcellular level through to the cell and tissue level and that these regulatory mechanisms specify cell and tissue fate by modifying the context of cellular signaling and gene expression. Here, we discuss the origin of these decision-making modules and illustrate how emergent properties of adhesion-directed multicellular structures sculpt the tissue, promote its functionality, and maintain its homeostasis through spatial segregation and organization of anchored proteins and secreted factors and through emergent properties of tissues, including tension fields and energy optimization.
Keywords AnimalsBiological EvolutionCell Adhesion/*physiologyCell Aggregation/physiologyCell CommunicationExtracellular Matrix/*physiologyGenotypeHomeostasisMorphogenesis/*physiologyPhenotypeProteins/chemistry/*physiologySignal Transduction/*physiology
PMID: 19359578
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.sciencemag.org/content/324/5924/208.full.pdf
Research group Migration cellulaire (645)
(ISO format)
ENGLER, Adam J. et al. Multiscale modeling of form and function. In: Science, 2009, vol. 324, n° 5924, p. 208-212. https://archive-ouverte.unige.ch/unige:19800

226 hits

1 download


Deposited on : 2012-04-23

Export document
Format :
Citation style :