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Curarisation residuelle et musculature pharyngee: restons vigilants!

Bourgain, J-L
Published in Annales françaises d'anesthésie et de réanimation. 2009, vol. 28, no. 10, p. 868-877
Abstract The different concepts treating of "residual curarization" were presented according to two directions: the analysis of their contents--epidemiologic, clinical, instrumental--and the description of the pharyngeal striated muscles functions in these contexts. It appears that certain, too marked, "residual curarization" levels remain a well-evidenced factor increasing some morbidities in numerous clinical situations. All the methods of instrumental monitoring of the level of curarization--mecanography, electromyography, accelerometry--appeared useful to document the levels of "residual curarization" before patient's extubation or awakening. Today, for our speciality, it became particularly clear that: neither the selected muscle-- adductor pollicis--, neither the test currently privileged--train-of-four 2Hz--, nor the thresholds currently selected--0.90 or 1.00--did not constitute the unavoidable proof of a "residual curarization" complete absence. For the healthy volunteer receiving a curare, a train of four of the adductor pollicis greater than 0.90 can exist in presence of spirometric alterations evidencing the lack of adequate pharyngeal dilatation. In daily routine, the pharyngeal control is already disturbed by numerous molecules including: benzodiazepines, halogenated vapours, propofol, i.e. even under non-hypnotic concentrations. Faced to such evidences, our medical speciality will, undoubtedly, have to acquire new knowledge to develop muscle relaxant management control processes eliminating the surmorbidities related to "residual curarization". These tests must be validated also to exclude morbidity-prone dysfunctions of the pharyngeal striated muscles. Considering this new paradigm would be a major safety evolution for our speciality.
Keywords Anesthetics/*pharmacology*Drug MonitoringHumansNeuromuscular Nondepolarizing Agents/*pharmacologyPharyngeal Muscles/*drug effects
PMID: 19854607
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D'HOLLANDER, Alain, BOURGAIN, J-L. Curarisation residuelle et musculature pharyngee: restons vigilants!. In: Annales françaises d'anesthésie et de réanimation, 2009, vol. 28, n° 10, p. 868-877. doi: 10.1016/j.annfar.2009.07.090 https://archive-ouverte.unige.ch/unige:19775

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