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Title

The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study

Authors
de Laat, B.
Pengo, V.
Pabinger, I.
Musial, J.
Voskuyl, A. E.
Bultink, I E. M.
Ruffatti, A.
Rozman, B.
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Published in Journal of Thrombosis and Haemostasis. 2009, vol. 7, no. 11, p. 1767-1773
Abstract BACKGROUND: Diagnosis of the antiphospholipid syndrome (APS) is difficult as a result of limited specificity of existing assays for detecting clinically relevant antiphospholipid antibodies. Anti-beta2-glycoprotein I (beta 2GPI) antibodies play a central role in the disease process of APS. OBJECTIVES: We have investigated the relation between antiphospholipid antibodies with specificity for domain I of beta 2GPI and thrombosis/pregnancy morbidity in an international multicenter study. PATIENTS/METHODS: Four hundred and seventy-seven patients derived from nine different centres met the inclusion criterion of having anti-beta 2GPI antibodies in their plasma/serum. Clinical data and results of tests for lupus anticoagulant, anti-cardiolipin antibodies and anti-beta 2GPI antibodies were established at the different centres of inclusion. After being re-tested for the presence of IgG and/or IgM anti-beta 2GPI antibodies, the samples were tested for the presence of IgG-directed against domain I of beta 2GPI and results were correlated with the thrombotic and obstetric history. RESULTS: Re-testing for the presence of anti-beta 2GPI antibodies resulted in inclusion of 442/477 patients. IgG class anti-domain I antibodies were present in plasma of 243/442 patients (55%). 201/243 (83%) had a history of thrombosis. This resulted in an odds ratio of 3.5 (2.3-5.4, 95% confidence interval) for thrombosis. Anti-domain I IgG antibodies were also significantly correlated with obstetric complications [odds ratio: 2.4 (1.4-4.3, 95% confidence interval)]. CONCLUSION: In this multicenter study, the detection of IgG antibodies that are directed against domain I of beta 2GPI proved to be more strongly associated with thrombosis and obstetric complications than those detected using the standard anti-beta 2GPI antibody assay.
Keywords AdolescentAdultAgedAged, 80 and overAntibodies, AntiphospholipidAntiphospholipid Syndrome/diagnosis/immunologyAutoantibodies/*bloodEpitopes/*immunologyFemaleHumansImmunoglobulin G/bloodMaleMiddle AgedPregnancyPregnancy Complications/immunologyThrombosis/diagnosis/*immunologyYoung AdultBeta 2-Glycoprotein I/*immunology
Identifiers
PMID: 19694946
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Research group Anticorps antiphospholipides (12)
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DE LAAT, B. et al. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. In: Journal of Thrombosis and Haemostasis, 2009, vol. 7, n° 11, p. 1767-1773. https://archive-ouverte.unige.ch/unige:19763

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Deposited on : 2012-04-23

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