UNIGE document Scientific Article
previous document  unige:19762  next document
add to browser collection
Title

Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients

Authors
de Jong, Mechteld C.
Pulitano, Carlo
Ribero, Dario
Strub, Jennifer
Schulick, Richard D.
Choti, Michael A.
Aldrighetti, Luca
show hidden authors show all authors [1 - 10]
Published in Annals of Surgery. 2009, vol. 250, no. 3, p. 440-448
Abstract OBJECTIVE(S): To investigate rates and patterns of recurrence in patients following curative intent surgery for colorectal liver metastasis. BACKGROUND: Outcomes following surgical management of colorectal liver metastasis have largely focused on overall survival. Contemporary data on rates and patterns of recurrence following surgery for colorectal liver metastasis are limited. METHODS: One thousand six hundred sixty-nine patients treated with surgery (resection +/- radiofrequency ablation [RFA]) for colorectal liver metastasis between 1982 and 2008 were identified from an international multi-institutional database. Clinicopathologic data, recurrence patterns, and recurrence-free survival (RFS) were analyzed. RESULTS: At the time of the initial liver-directed surgery, surgical treatment was resection only (90.2%), resection plus RFA (8.0%), or RFA alone (1.8%). While 5-year overall survival was 47.3%, 947 (56.7%) patients recurred with a median RFS time of 16.3 months. First recurrence site was intrahepatic only (43.2%), extrahepatic only (35.8%), intra- and extrahepatic (21.0%). There was no difference in RFS based on site of recurrence (intrahepatic: 16.9 months; extrahepatic: 16.6 months; intra- and extrahepatic: 16.2 month; P > 0.05). Receipt of adjuvant chemotherapy was associated with overall recurrence risk (hazard ratio [HR] = 0.56), while history of RFA (HR = 2.39, P = 0.001) and R1 margin status (HR = 1.36) were predictive of intrahepatic recurrence. Pattern of recurrence and RFS remained similar following repeat surgery for recurrent disease. CONCLUSIONS: While 5-year survival following surgery for colorectal liver metastasis approaches 50%, over one-half of patients develop recurrence within 2 years. The pattern of failure is distributed relatively equally among intrahepatic, extrahepatic, and intra- plus extrahepatic sites. Patients undergoing repeat surgery for recurrent metastasis have similar patterns of recurrence and RFS time.
Keywords AdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy Protocols/administration & dosageCatheter AblationChemotherapy, AdjuvantColorectal Neoplasms/*pathologyFemaleHumansLiver Neoplasms/drug therapy/*secondary/*surgeryMaleMiddle AgedNeoplasm Recurrence, LocalPredictive Value of TestsProportional Hazards ModelsStatistics, NonparametricSurvival RateTreatment Outcome
Identifiers
PMID: 19730175
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Hépatologie chirurgicale (327)
Citation
(ISO format)
DE JONG, Mechteld C. et al. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. In: Annals of Surgery, 2009, vol. 250, n° 3, p. 440-448. https://archive-ouverte.unige.ch/unige:19762

182 hits

0 download

Update

Deposited on : 2012-04-23

Export document
Format :
Citation style :